Results 71 to 80 of about 10,810 (302)

SLAMF6 compartmentalization enhances T cell functions

Life Science Alliance, 2022
Signaling lymphocyte activation molecule family member 6 (SLAMF6) is a T cell co-receptor. Previously, we showed that SLAMF6 clustering was required for T cell activation. To better understand the relationship between SLAMF6 location and function and to evaluate the role of SLAMF6 as a therapeutic target, we investigated how its compartmentalization on
Yevgeniya Gartshteyn, Anca D Askanase, Ruijiang Song, Shoiab Bukhari, Matthew Dragovich, Kieran Adam, Adam Mor   +6 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Subcellular compartmentation of ascorbate and its variation in disease states.

, 2014
Beyond its general role as antioxidant, specific functions of ascorbate are compartmentalized within the eukaryotic cell. The list of organelle-specific functions of ascorbate has been recently expanded with the epigenetic role exerted as a cofactor for ...
Benedetti A, Nemeth, Csilla E., Fulceri, Rosella, Benedetti, Angiolo, Rosella Fulceri, Paola Marcolongo, Gábor Bánhegyi, Angelo Benedetti, Marcolongo, Paola, Szarka, András, Németh, Csilla E, Margittai, Éva, Benedetti, Angelo, Marcolongo P, Csilla E. Németh, Éva Margittai, Bánhegyi, Gábor, Németh, Csilla Emese, Fulceri R, András Szarka   +19 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Rapid fractionation of mitochondria from mouse liver and heart reveals in vivo metabolite compartmentation.

, 2022
The compartmentation and distribution of metabolites between mitochondria and the rest of the cell is a key parameter of cell signalling and pathology. Here, we have developed a rapid fractionation procedure that enables us to take mouse heart and liver ...

core   +1 more source

Regulation of membrane-bound enzymes of glycosphingolipid biosynthesis

Journal of Lipid Research, 1984
The descriptive phase of glycosphingolipid biochemistry has blossomed over the past decade with the application of exquisitely sensitive analytical methods of mass spectrometry, NMR, and monoclonal antibody technology.
J D Burczak, R M Soltysiak, C C Sweeley
doaj   +1 more source

Shape control and compartmentalization in active colloidal cells [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Advances in simulation and synthesis of nanoparticles and colloids are leading to a new class of active colloidal systems where self-propelled and self-rotated particles convert energy to motion. Such systems hold promise for the possibility of colloidal machines––integrated systems of colloids able to carry out functions.
Matthew, Spellings, Michael, Engel, Daphne, Klotsa, Syeda, Sabrina, Aaron M, Drews, Nguyen H P, Nguyen, Kyle J M, Bishop, Sharon C, Glotzer   +7 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Compartmentation of metabolism within mitochondria and plastids

, 2001
An important component of metabolic regulation is compartmentation and specialization. Subcellular compartmentation and the role of individual organelles is well studied, though less consideration has been given to the extent to which organelles differ ...
Bowsher, CG, Bowsher, Caroline G., Tobin, Alyson Kim, Tobin, Alyson K.   +3 more
core   +1 more source

Root-specific theanine metabolism and regulation at the single-cell level in tea plants (Camellia sinensis)

eLife
Root-synthesized secondary metabolites are critical quality-conferring compounds of foods, plant-derived medicines, and beverages. However, information at a single-cell level on root-specific secondary metabolism remains largely unexplored.
Shijia Lin, Yiwen Zhang, Shupei Zhang, Yijie Wei, Mengxue Han, Yamei Deng, Jiayi Guo, Biying Zhu, Tianyuan Yang, Enhua Xia, Xiaochun Wan, William J Lucas, Zhaoliang Zhang   +12 more
doaj   +1 more source