Results 61 to 70 of about 9,936 (260)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Root-specific theanine metabolism and regulation at the single-cell level in tea plants (Camellia sinensis)

eLife
Root-synthesized secondary metabolites are critical quality-conferring compounds of foods, plant-derived medicines, and beverages. However, information at a single-cell level on root-specific secondary metabolism remains largely unexplored.
Shijia Lin, Yiwen Zhang, Shupei Zhang, Yijie Wei, Mengxue Han, Yamei Deng, Jiayi Guo, Biying Zhu, Tianyuan Yang, Enhua Xia, Xiaochun Wan, William J Lucas, Zhaoliang Zhang   +12 more
doaj   +1 more source

Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution

Biology Direct, 2010
Background The transition from prokaryotes to eukaryotes was the most radical change in cell organisation since life began, with the largest ever burst of gene duplication and novelty.
Cavalier-Smith Thomas
doaj   +1 more source

Shape control and compartmentalization in active colloidal cells [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Advances in simulation and synthesis of nanoparticles and colloids are leading to a new class of active colloidal systems where self-propelled and self-rotated particles convert energy to motion. Such systems hold promise for the possibility of colloidal machines––integrated systems of colloids able to carry out functions.
Matthew, Spellings, Michael, Engel, Daphne, Klotsa, Syeda, Sabrina, Aaron M, Drews, Nguyen H P, Nguyen, Kyle J M, Bishop, Sharon C, Glotzer   +7 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Segregation of fluorescent membrane lipids into distinct micrometric domains: evidence for phase compartmentation of natural lipids?

PLoS ONE, 2011
BackgroundWe recently reported that sphingomyelin (SM) analogs substituted on the alkyl chain by various fluorophores (e.g. BODIPY) readily inserted at trace levels into the plasma membrane of living erythrocytes or CHO cells and spontaneously ...
Ludovic D'auria, Patrick Van der Smissen, Frédéric Bruyneel, Pierre J Courtoy, Donatienne Tyteca   +4 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Sobre la ecofisiología de plantas halofitas y desérticas

Acta Biológica Colombiana, 1990
Some aspects of the tolerance of higher plants to salt environments and dry zones are pointed out. Salt and drought tolerance arc mostly based on selective ion absorption, osmoregulation, cell compartmentation and synthesis of osmotic compounds.
Albert R. F. Hotterer, G. Hertenberger, J. Polanía   +2 more
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source