Results 11 to 20 of about 10,810 (302)
Cells, 2022 The therapeutic benefit of stimulating the cGMP pathway as a form of treatment to combat heart failure, as well as other fibrotic pathologies, has become well established.
Maria Faleeva +11 more
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Role of EPAC1 Signalosomes in Cell Fate: Friends or Foes?
Cells, 2020 The compartmentation of signaling processes is accomplished by the assembly of protein complexes called signalosomes. These signaling platforms colocalize enzymes, substrates, and anchoring proteins into specific subcellular compartments.
Karina Formoso +2 more
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Redox compartmentalization in eukaryotic cells [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2008 Diverse functions of eukaryotic cells are optimized by organization of compatible chemistries into distinct compartments defined by the structures of lipid-containing membranes, multiprotein complexes and oligomeric structures of saccharides and nucleic acids.
Young-Mi, Go, Dean P, Jones
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The PKD-Dependent Biogenesis of TGN-to-Plasma Membrane Transport Carriers
Cells, 2021 Membrane trafficking is essential for processing and transport of proteins and lipids and to establish cell compartmentation and tissue organization. Cells respond to their needs and control the quantity and quality of protein secretion accordingly.
Yuichi Wakana, Felix Campelo
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Extreme Compartmentalization in a Drosophila Amacrine Cell [PDF]
Current Biology, 2019 A neuron is conventionally regarded as a single processing unit. It receives input from one or several presynaptic cells, transforms these signals, and transmits one output signal to its postsynaptic partners. Exceptions exist: amacrine cells in the mammalian retina [1-3] or interneurons in the locust mesothoracic ganglion [4] are thought to represent ...
Meier, M., Borst, A.
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Phase separation of a PKA regulatory subunit controls cAMP compartmentation and oncogenic signaling [PDF]
, 2020 The fidelity of intracellular signaling hinges on the organization of dynamic activity architectures. Spatial compartmentation was first proposed over 30 years ago to explain how diverse G protein-coupled receptors achieve specificity despite converging ...
Yang, J.R. +21 more
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Moonlight functions of glycolytic enzymes in cancer
Frontiers in Molecular Biosciences, 2023 Since an extensive genome research has started, basic principle “one gene—one protein—one function” was significantly revised. Many proteins with more than one function were identified and characterized as “moonlighting” proteins, which activity depend ...
Petr V. Shegay +9 more
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Copper Transport and Compartmentation in Grape Cells [PDF]
Plant and Cell Physiology, 2012 Copper-based fungicides have been widely used against several grapevine (Vitis vinifera L.) diseases since the late 1800s when the Bordeaux mixture was developed, but their intensive use has raised phytotoxicity concerns. In this study, physiological, biochemical and molecular approaches were combined to investigate the impacts of copper in grape cells
Viviana, Martins +3 more
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Tight coupling of Na+/K+-ATPase with glycolysis demonstrated in permeabilized rat cardiomyocytes. [PDF]
PLoS ONE, 2014 The effective integrated organization of processes in cardiac cells is achieved, in part, by the functional compartmentation of energy transfer processes.
Mervi Sepp +5 more
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Reorganization of Cell Compartmentalization Induced by Stress
Biomolecules, 2022 The discovery of intrinsically disordered proteins (IDPs) that do not have an ordered structure and nevertheless perform essential functions has opened a new era in the understanding of cellular compartmentalization. It threw the bridge from the mostly mechanistic model of the organization of the living matter to the idea of highly dynamic and ...
Anna S. Fefilova +5 more
openaire +3 more sources