Results 31 to 40 of about 10,810 (302)

Compartmentalized Production of Ceramide at the Cell Surface [PDF]

open access: yesJournal of Biological Chemistry, 1995
Ceramide produced by the hydrolysis of sphingomyelin is an important cellular intermediate in hormone action. Here, we present evidence that interleukin 1 beta (IL-1 beta) binding to normal human fibroblasts initiates a lipid messenger cascade that takes place in a sphingomyelin-rich plasma membrane domain with the characteristics of caveolae.
P, Liu, R G, Anderson
openaire   +2 more sources

Modulation in Wistar rats of blood corticosterone compartmentation by sex and a cafeteria diet. [PDF]

open access: yesPLoS ONE, 2013
In the metabolic syndrome, glucocorticoid activity is increased, but circulating levels show little change. Most of blood glucocorticoids are bound to corticosteroid-binding globulin (CBG), which liver expression and circulating levels are higher in ...
María del Mar Romero   +6 more
doaj   +1 more source

The Development of Compartmentation of cAMP Signaling in Cardiomyocytes: The Role of T-Tubules and Caveolae Microdomains

open access: yesJournal of Cardiovascular Development and Disease, 2018
3′-5′-cyclic adenosine monophosphate (cAMP) is a signaling messenger produced in response to the stimulation of cellular receptors, and has a myriad of functional applications depending on the cell type.
Navneet K. Bhogal   +2 more
doaj   +1 more source

Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen [PDF]

open access: yes, 2008
Spermatogenesis in the adult male depends on the action of FSH and androgen. Ablation of either hormone has deleterious effects on Sertoli cell function and the progression of germ cells through spermatogenesis.
Baker, P.J.   +8 more
core   +1 more source

Non-aqueous fractionation revealed changing subcellular metabolite distribution during apple fruit development

open access: yesHorticulture Research, 2019
In developing apple fruit, metabolic compartmentation is poorly understood due to the lack of experimental data. Distinguishing subcellular compartments in fruit using non-aqueous fractionation has been technically difficult due to the excess amount of ...
Wasiye F. Beshir   +6 more
doaj   +1 more source

Abscisic acid dynamics in roots detected with genetically encoded FRET sensors

open access: yeseLife, 2014
Cytosolic hormone levels must be tightly controlled at the level of influx, efflux, synthesis, degradation and compartmentation. To determine ABA dynamics at the single cell level, FRET sensors (ABACUS) covering a range ∼0.2–800 µM were engineered using ...
Alexander M Jones   +5 more
doaj   +1 more source

The Phenylpropanoid Case – It Is Transport That Matters

open access: yesFrontiers in Plant Science, 2018
Phenylpropanoids fulfill numerous physiological functions, essential for plant growth and development, as well as plant–environment interactions. Over the last few decades, many studies have shown that exquisite regulatory mechanisms at multiple levels ...
Wanda Biała   +2 more
doaj   +1 more source

Ultrastructural Alterations in Cells of Sunflower Linear Glandular Trichomes during Maturation

open access: yesPlants, 2021
Sunflower and related taxa are known to possess a characteristic type of multicellular uniseriate trichome which produces sesquiterpenes and flavonoids of yet unknown function for this plant. Contrary to the metabolic profile, the cytological development
Evelyn Amrehn, Otmar Spring
doaj   +1 more source

SENIEUR status of the originating cell donor negates certain ‘anti-immunosenescence’ effects of ebselen and N-acetyl cysteine in human T cell clone cultures [PDF]

open access: yes, 2014
Background: Damage to T cells of the immune system by reactive oxygen species may result in altered cell function or cell death and thereby potentially impact upon the efficacy of a subsequent immune response.
Pawelec, Graham   +19 more
core   +1 more source

Functional compartmentalization and metabolic separation in a prokaryotic cell [PDF]

open access: yesProceedings of the National Academy of Sciences, 2021
Significance In a typical prokaryotic cell, hundreds of metabolites are present and interconverted simultaneously, some serving as allosteric regulators for unrelated reactions or accidental substrates for promiscuous enzymes or being downright reactive and toxic.
Jennifer Flechsler   +4 more
openaire   +3 more sources

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