Results 1 to 10 of about 16,798,617 (404)
Complete replication of hepatitis C virus in cell culture. [PDF]
Science, 2005 Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen.
Burton, Dennis R +10 more
core +2 more sources
Presence of pyrroloquinazoline alkaloid in Adhatoda vasica attenuates inflammatory response through the downregulation of pro-inflammatory mediators in LPS stimulated RAW 264.7 macrophages [PDF]
BioImpacts, 2021 Introduction: Inflammation is the primary response caused due to harmful stimuli which are followed by the increased draining of plasma and immune cells from the body into the site of the injured tissue.
Reddy Amala, Sundaresan Sujatha
doaj +1 more source
mAbs, 2023 Introns are included in genes encoding therapeutic proteins for their well-documented function of boosting expression. However, mis-splicing of introns in recombinant immunoglobulin (IgG) heavy chain (HC) transcripts can produce amino acid sequence ...
Emma Kelsall +5 more
doaj +1 more source
3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages
International Journal of Molecular Sciences, 2021 The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long been used in cancer research. However, this system cannot be fully translated into clinical trials to ideally represent physiological conditions.
O. Habanjar +3 more
semanticscholar +1 more source
Cancers, 2021 Simple Summary Three-dimensional (3D) cell culture models have been proposed as alternatives for initial drug screening to increase drug development efficiency.
Mélanie A. G. Barbosa +4 more
semanticscholar +1 more source
A Novel 2.5D Culture Platform to Investigate the Role of Stiffness Gradients on Adhesion-Independent Cell Migration [PDF]
, 2014 Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness.
Asuri, Prashanth +2 more
core +10 more sources
Gene Expression and Immunochemistry Analysis of ADAMTS-1 and Versican in Ameloblastoma
International Journal of Dentistry, 2022 Background. Ameloblastoma is a benign but locally invasive odontogenic epithelial tumor, associated with a high recurrence rate after treatment. The action of enzymes of the metalloproteinase family is important to the degraded extracellular matrix ...
Osvaldo Rodrigues de Souza Neto +4 more
doaj +1 more source
International Journal of Molecular Sciences, 2021 The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations.
Yujin Park, K. Huh, Sun-Woong Kang
semanticscholar +1 more source
Diagnostic Pathology, 2021 Background Oral squamous cell carcinoma (OSCC) is the most relevant malignant neoplasm among all head and neck tumours due to its high prevalence and unfavourable prognosis.
Geovanni Pereira Mitre +5 more
doaj +1 more source
Is It Time to Start Transitioning From 2D to 3D Cell Culture?
Frontiers in Molecular Biosciences, 2020 Cell culture is an important and necessary process in drug discovery, cancer research, as well as stem cell study. Most cells are currently cultured using two-dimensional (2D) methods but new and improved methods that implement three-dimensional (3D ...
Caleb Jensen, Yong Teng
semanticscholar +1 more source