Results 1 to 10 of about 17,149,914 (409)

Decellularized lymph node sections with preserved extracellular matrix for stromal cell culture. [PDF]

Sci Rep
Esparza E, Teles LN, Fedotova A, Dehaseth N, Sayegh M, Hernandez AV, Ho LY, Ziebarth NM, Tomei AA.   +8 more
europepmc   +3 more sources

Presence of pyrroloquinazoline alkaloid in Adhatoda vasica attenuates inflammatory response through the downregulation of pro-inflammatory mediators in LPS stimulated RAW 264.7 macrophages [PDF]

BioImpacts, 2021
Introduction: Inflammation is the primary response caused due to harmful stimuli which are followed by the increased draining of plasma and immune cells from the body into the site of the injured tissue.
Reddy Amala, Sundaresan Sujatha
doaj   +1 more source

Interplay of heavy chain introns influences efficient transcript splicing and affects product quality of recombinant biotherapeutic antibodies from CHO cells

mAbs, 2023
Introns are included in genes encoding therapeutic proteins for their well-documented function of boosting expression. However, mis-splicing of introns in recombinant immunoglobulin (IgG) heavy chain (HC) transcripts can produce amino acid sequence ...
Emma Kelsall, Claire Harris, Titash Sen, Diane Hatton, Sarah Dunn, Suzanne Gibson   +5 more
doaj   +1 more source

3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages

International Journal of Molecular Sciences, 2021
The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long been used in cancer research. However, this system cannot be fully translated into clinical trials to ideally represent physiological conditions.
O. Habanjar, M. Diab‐Assaf, F. Caldefie-Chézet, L. Delort   +3 more
semanticscholar   +1 more source

3D Cell Culture Models as Recapitulators of the Tumor Microenvironment for the Screening of Anti-Cancer Drugs

Cancers, 2021
Simple Summary Three-dimensional (3D) cell culture models have been proposed as alternatives for initial drug screening to increase drug development efficiency.
Mélanie A. G. Barbosa, C. P. Xavier, R. Pereira, V. Petrikaitė, M. Vasconcelos   +4 more
semanticscholar   +1 more source

Gene Expression and Immunochemistry Analysis of ADAMTS-1 and Versican in Ameloblastoma

International Journal of Dentistry, 2022
Background. Ameloblastoma is a benign but locally invasive odontogenic epithelial tumor, associated with a high recurrence rate after treatment. The action of enzymes of the metalloproteinase family is important to the degraded extracellular matrix ...
Osvaldo Rodrigues de Souza Neto, Hellen Thais Fuzii, Suély Vieira Da Silva, Vanessa Morais Freitas, João de Jesus Viana Pinheiro   +4 more
doaj   +1 more source

3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration

Clinical and Translational Science, 2021
Nonclinical testing has served as a foundation for evaluating potential risks and effectiveness of investigational new drugs in humans. However, the current two‐dimensional (2D) in vitro cell culture systems cannot accurately depict and simulate the rich
Hongbing Wang, Paul C. Brown, E. Chow, L. Ewart, S. Ferguson, S. Fitzpatrick, Benjamin S. Freedman, G. Guo, W. Hedrich, S. Heyward, J. Hickman, N. Isoherranen, Albert P. Li, Qi Liu, S. Mumenthaler, J. Polli, W. Proctor, A. Ribeiro, Jian-Ying Wang, R. Wange, Shiew-Mei Huang   +20 more
semanticscholar   +1 more source

Key proteins of invadopodia are overexpressed in oral squamous cell carcinoma suggesting an important role of MT1-MMP in the tumoral progression

Diagnostic Pathology, 2021
Background Oral squamous cell carcinoma (OSCC) is the most relevant malignant neoplasm among all head and neck tumours due to its high prevalence and unfavourable prognosis.
Geovanni Pereira Mitre, Karolyny Martins Balbinot, André Luis Ribeiro Ribeiro, Maria Sueli da Silva Kataoka, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro   +5 more
doaj   +1 more source

Is It Time to Start Transitioning From 2D to 3D Cell Culture?

Frontiers in Molecular Biosciences, 2020
Cell culture is an important and necessary process in drug discovery, cancer research, as well as stem cell study. Most cells are currently cultured using two-dimensional (2D) methods but new and improved methods that implement three-dimensional (3D ...
Caleb Jensen, Yong Teng
semanticscholar   +1 more source

Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

International Journal of Molecular Sciences, 2021
The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations.
Yujin Park, K. Huh, Sun-Woong Kang
semanticscholar   +1 more source