Results 111 to 120 of about 17,041,985 (363)

The inhibitory SAPS3–AMPK interaction detected in HEK293 cells is not detectable in muscle or liver from humans or mice

FEBS Letters, EarlyView.
This study challenges the idea that Sit4‐associated protein subunit 3 (SAPS3) inhibits the energy‐sensing enzyme AMP‐activated protein kinase (AMPK) in muscle and liver tissue. Although SAPS3 interacts with AMPK in cultured cells, we found no such interaction in human or mouse tissues subjected to fasting, exercise, or a high‐fat diet.
Jesper B. Birk, Maria A. Møller, Jørgen F.P. Wojtaszewski, Rasmus Kjøbsted   +3 more
wiley   +1 more source

Caspase Mediated Enhanced Apoptotic Action of Cyclophosphamide- and Resveratrol-Treated MCF-7 Cells

Journal of Pharmacological Sciences, 2009
Cyclophosphamide (CPA) is a widely used chemotherapeutic drug for neoplasias. It is a DNA and protein alkylating agent having a broad spectrum of activity against a variety of neoplasms including breast cancer.
Neetu Singh, Manisha Nigam, Vishal Ranjan, Ramesh Sharma, Anil Kumar Balapure, Srikanta Kumar Rath   +5 more
doaj   +1 more source

Characterization of a continuous feline mammary epithelial cell line susceptible to feline epitheliotropic viruses. [PDF]

, 2009
Mucosal epithelial cells are the primary targets for many common viral pathogens of cats. Viral infection of epithelia can damage or disrupt the epithelial barrier that protects underlying tissues.
Heymer, Anna, Liu, Hongwei, Millon, Lee, Ossiboff, Robert J, Parker, John SL, Pesavento, Patricia, Stucker, Karla M, van der List, Deborah, Wood, Jason   +8 more
core  

Multiple effects of silymarin on the hepatitis C virus lifecycle [PDF]

, 2010
Silymarin, an extract from milk thistle (Silybum marianum), and its purified flavonolignans have been recently shown to inhibit hepatitis C virus (HCV) infection, both in vitro and in vivo.
Bourne, Nigel, Brimacombe, Claire L, Cao, Feng, Graf, Tyler N, Grove, Joe, Kane, Olivia J, Lohmann, Volker, Martinez, Laura E, McKeating, Jane A, Nahmias, Yaakov, Negash, Amina, Oberlies, Nicholas H, Owen, David M, Polyak, Stephen J, Pécheur, Eve-Isabelle, Tavis, John E, Wagoner, Jessica   +16 more
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy

Stem Cells International, 2016
Although mesenchymal stem cells (MSCs) based therapy has been considered as a promising tool for tissue repair and regeneration, the optimal cell source remains unknown.
Huaijuan Ren, Yunxia Sang, Fengli Zhang, Zhaoqing Liu, Nianmin Qi, Yantian Chen   +5 more
doaj   +1 more source

Improving single-cell cloning workflow for gene editing in human pluripotent stem cells [PDF]

, 2018
The availability of human pluripotent stem cells (hPSCs) and progress in genome engineering technology have altered the way we approach scientific research and drug development screens.
Chen, Yi-Hsien, Pruett-Miller, Shondra M
core   +2 more sources

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Saccharomyces cerevisiae morphological changes and cytokinesis arrest elicited by hypoxia during scale-up for production of therapeutic recombinant proteins

Microbial Cell Factories, 2018
Background Scaling up of bioprocesses represents a crucial step in the industrial production of biologicals. However, our knowledge about the impact of scale-up on the organism’s physiology and function is still incomplete.
Juan C. Aon, Ricardo C. Tecson, Vakhtang Loladze   +2 more
doaj   +1 more source

Attenuated African swine fever virus through serial passaging of viruses in cell culture: a brief review on the knowledge gathered during 60 years of research [PDF]

, 2022
Xiaoyue Zhang, Zhenzhong Wang, Shengqiang Ge, Yuanyuan Zuo, Haodong Lu, Yan Lv, Naijun Han, Yumei Cai, Xiaodong Wu, Zhiliang Wang   +9 more
openalex   +1 more source