Results 11 to 20 of about 15,168,841 (359)

Presence of pyrroloquinazoline alkaloid in Adhatoda vasica attenuates inflammatory response through the downregulation of pro-inflammatory mediators in LPS stimulated RAW 264.7 macrophages [PDF]

BioImpacts, 2021
Introduction: Inflammation is the primary response caused due to harmful stimuli which are followed by the increased draining of plasma and immune cells from the body into the site of the injured tissue.
Reddy Amala, Sundaresan Sujatha
doaj   +1 more source

3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages

International Journal of Molecular Sciences, 2021
The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long been used in cancer research. However, this system cannot be fully translated into clinical trials to ideally represent physiological conditions.
O. Habanjar, M. Diab‐Assaf, F. Caldefie-Chézet, L. Delort   +3 more
semanticscholar   +1 more source

Interplay of heavy chain introns influences efficient transcript splicing and affects product quality of recombinant biotherapeutic antibodies from CHO cells

mAbs, 2023
Introns are included in genes encoding therapeutic proteins for their well-documented function of boosting expression. However, mis-splicing of introns in recombinant immunoglobulin (IgG) heavy chain (HC) transcripts can produce amino acid sequence ...
Emma Kelsall, Claire Harris, Titash Sen, Diane Hatton, Sarah Dunn, Suzanne Gibson   +5 more
doaj   +1 more source

3D Cell Culture Models as Recapitulators of the Tumor Microenvironment for the Screening of Anti-Cancer Drugs

Cancers, 2021
Simple Summary Three-dimensional (3D) cell culture models have been proposed as alternatives for initial drug screening to increase drug development efficiency.
Mélanie A. G. Barbosa, C. P. Xavier, R. Pereira, V. Petrikaitė, M. Vasconcelos   +4 more
semanticscholar   +1 more source

Gene Expression and Immunochemistry Analysis of ADAMTS-1 and Versican in Ameloblastoma

International Journal of Dentistry, 2022
Background. Ameloblastoma is a benign but locally invasive odontogenic epithelial tumor, associated with a high recurrence rate after treatment. The action of enzymes of the metalloproteinase family is important to the degraded extracellular matrix ...
Osvaldo Rodrigues de Souza Neto, Hellen Thais Fuzii, Suély Vieira Da Silva, Vanessa Morais Freitas, João de Jesus Viana Pinheiro   +4 more
doaj   +1 more source

Applications of Biomaterials in 3D Cell Culture and Contributions of 3D Cell Culture to Drug Development and Basic Biomedical Research

International Journal of Molecular Sciences, 2021
The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations.
Yujin Park, K. Huh, Sun-Woong Kang
semanticscholar   +1 more source

Key proteins of invadopodia are overexpressed in oral squamous cell carcinoma suggesting an important role of MT1-MMP in the tumoral progression

Diagnostic Pathology, 2021
Background Oral squamous cell carcinoma (OSCC) is the most relevant malignant neoplasm among all head and neck tumours due to its high prevalence and unfavourable prognosis.
Geovanni Pereira Mitre, Karolyny Martins Balbinot, André Luis Ribeiro Ribeiro, Maria Sueli da Silva Kataoka, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro   +5 more
doaj   +1 more source

Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells

Scientific Reports, 2020
One major challenge observed for the expression of therapeutic bispecific antibodies (BisAbs) is high product aggregates. Aggregates increase the risk of immune responses in patients and therefore must be removed at the expense of purification yields ...
Pritam Sinharoy, Aaron H. Aziz, Natalia I. Majewska, Sanjeev Ahuja, Michael W. Handlogten   +4 more
doaj   +1 more source

Molluscan cells in culture: primary cell cultures and cell lines [PDF]

Canadian Journal of Zoology, 2013
In vitro cell culture systems from molluscs have significantly contributed to our basic understanding of complex physiological processes occurring within or between tissue-specific cells, yielding information unattainable using intact animal models.
U Bickham, Timothy P. Yoshino, Christopher J. Bayne   +2 more
openaire   +3 more sources

Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards

European Journal of Clinical Microbiology and Infectious Diseases, 2020
In a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients.
B. La Scola, M. Le Bideau, J. Andreani, V. Hoang, Clio Grimaldier, P. Colson, P. Gautret, D. Raoult   +7 more
semanticscholar   +1 more source