A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
, 2002 The purpose of this article is to discuss small-group apprenticeships (SGAs) as a method to in-struct cell culture techniques to high school participants.
Sumant Kulcarni +7 more
core +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Galactosylation of rat natural scaffold for MSC differentiation into hepatocyte-like cells: A comparative analysis of 2D vs. 3D cell culture techniques. [PDF]
Biochem Biophys Rep, 2023 Vazirzadeh M +3 more
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Using Advanced Cell Culture Techniques to Differentiate Pluripotent Stem Cells and Recreate Tissue Structures Representative of Teratoma Xenografts. [PDF]
Front Cell Dev Biol, 2021 Smith LA +5 more
europepmc +1 more source
Journal of Oral MicrobiologyObjective The aim of the present study was to characterize the antimicrobial and anti-inflammatory activities of postbiotics from lactic acid bacteria against Porphyromonas gingivalis.Material and methods The anti-P.
Johana R. Naja +6 more
doaj +1 more source
An Extensive Method for Maintenance of Sterility in Mammalian Cell Culture Laboratory Routine
Challenges, 2017 Cell culture laboratories are designed to secure sterile environments for biological studies, and its susceptibility to biological contaminants is a major problem for researchers.
Selcen Çelik-Uzuner, Uğur Uzuner
doaj +1 more source
Practical Cell Culture Techniques [electronic resource] /
Most cells will survive removal from the natural mic- environment of their in vivo tissue and placement into a sterile culture dish under optimal conditions. Not only do they survive, but they also multiply and express differen- ated properties in such a
Walz, Wolfgang.editor.edthttp://id.loc.gov/vocabulary/relators/edt +3 more
core +1 more source
The effect of in vitro culture on the stability, expansion and neuronal differentiation of human pluripotent cell lines [PDF]
, 2010 Pluripotent cells are defined by their ability to both self-renew and to differentiation into any cell type within the human body. As such, pluripotent cell lines are of great interest as starting material for drug screening and cell therapies for ...
Gillett, M L, Gillett, M.L.
core