Results 111 to 120 of about 14,342,616 (323)
PP2A as a master regulator of the cell cycle
Critical reviews in biochemistry and molecular biology, 2016 Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell cycle, regulating almost all major pathways and cell cycle checkpoints. PP2A is
N. Wlodarchak, Y. Xing
semanticscholar +1 more source
Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance
Molecular Oncology, EarlyView.In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang +8 more
wiley +1 more source
Simulating cell populations with explicit cell cycle length -- implications to cell cycle dependent tumour therapy [PDF]
arXivIn this study, we present a stochastic simulation model designed to explicitly incorporate cell cycle length, overcoming limitations associated with classical compartmental models. Our approach employs a delay mechanism to represent the cell cycle, allowing the use of arbitrary distributions for cell cycle lengths. We demonstrate the feasibility of our
arxiv
In vitro investigation of the effects of X- rays carried by a photon beam upon the cell cycle progression in Vero cells [PDF]
arXiv, 2013 The effects of the X-rays carried out in a photon beam produced by a medical linear particle accelerator on the progression of the cell cycle in normal cells Vero were evaluated by flow cytometric mean. The evaluation of the consequences of 1 and 3 Gy irradiation upon cell cycle development was performed after 96 and 120 hours from the exposure moment,
arxiv
The MCM2-7 Complex: Roles beyond DNA Unwinding
BiologyThe MCM2-7 complex is a hexameric protein complex that serves as a DNA helicase. It unwinds the DNA double helix during DNA replication, thereby providing the single-stranded replication template.
Brooke D. Rankin, Susannah Rankin
doaj +1 more source
Molecular Oncology, EarlyView.This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang +10 more
wiley +1 more source
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin
Nature Communications, 2016 Previous studies suggest that Cyclin D1 may regulate cell adhesion and migration but the mechanisms underlying such regulation and the relevance to cancer development are unknown. Here, Fusté et al.
Noel P. Fusté +10 more
doaj +1 more source
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
Development, 2013 Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities are modulated by interactions with cyclins and Cdk inhibitors (CKIs).
Shuhui Lim, P. Kaldis
semanticscholar +1 more source
Molecular Oncology, EarlyView.VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park +6 more
wiley +1 more source