Results 221 to 230 of about 1,815,617 (316)

Overexpression of heat-shock protein 25 augments radiation-induced cell-cycle arrest in murine L929 cells

, 2001
H.-N. Cho, S.-J. Lee, S.-H. Park, Yong J. Lee, C.-K. Cho, Yebin Lee   +5 more
openalex   +2 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

The pyrrolizidine alkaloid lasiocarpine impairs cell cycle progression in vitro. [PDF]

Arch Toxicol
Hessel-Pras S, Beckschulte M, Peters A, Koellner A, Rosskopp B, Stahl A, Templin M, Sprenger H, Boehmert L, Kuepper JH, Sachse B, Schaefer B.   +11 more
europepmc   +1 more source

Analgecine enhances the anti-tumor response of radiotherapy by increasing apoptosis and cell cycle arrest in non-small cell lung cancer

, 2017
Xue Chen, Xibing Zhuang, Qi Zhang, Youjun Luo, Sujuan Yuan, Tiankui Qiao   +5 more
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

SNX1 inhibits human ovarian cancer progression via regulation of the cell cycle, apoptosis and migration. [PDF]

Mol Cell Oncol
Li P, Yu X, Wen K, Wang L, Yu J, Chen P.
europepmc   +1 more source

EPAS1 increases SDHA to inhibit proliferation of multiple myeloma cells by restoring TCA Cycle [PDF]

Yifeng Sun, Aziguli Maihemaiti, Xu Zhao, Lu Tang, Yawen Wang, Jifeng Jiang, Hui Zhou, Cuizhen Pan, Yuyang Pang, Peng Liu   +9 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Transcriptome analysis unveils Th1 cell cycle signature as a distinctive feature of mixed connective tissue disease. [PDF]

Arthritis Res Ther
Suwa Y, Nagafuchi Y, Yamada S, Maeda J, Ota M, Tsuchida Y, Shoda H, Okamura T, Fujio K.   +8 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source