Results 241 to 250 of about 3,524,174 (306)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

<i>Lyar</i> contributes to cell cycle progression and multi-lineage differentiation in mouse embryonic stem cells. [PDF]

Front Genet
Pan Y, Su Y, Xing L, Yao M.
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Correction: Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway

Molecular Cancer
Joshua E Allen, Gabriel Krigsfeld, Luv Patel, Patrick A Mayes, David T Dicker, Gen Sheng Wu, Wafik S El-Deiry   +6 more
doaj   +1 more source

Multi-omics analysis identifies BUB1B as a cell cycle-related driver of bladder cancer progression. [PDF]

World J Surg Oncol
Zhou H, Peng S, Ling Z, Cai J, Liu J, Kong Y, Zhang H, Ouyang J, Zhang J.   +8 more
europepmc   +1 more source

Cell cycle criticality as a mechanism for robust cell population control. [PDF]

Mol Syst Biol
Simons BD, Karin O.
europepmc   +1 more source

Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions. [PDF]

Nat Cell Biol
He S, Lemma LM, Martinez-Calvo A, He G, Hennacy JH, Wang L, Ergun SL, Rai AK, Wang C, Bunday L, Kayser-Browne A, Wang Q, Brangwynne CP, Wingreen NS, Jonikas MC.   +14 more
europepmc   +1 more source

USP7 at the Crossroads of Ubiquitin Signaling, Cell Cycle, and Tumorigenesis. [PDF]

Molecules
Lusardi M, Rapetti F, Spallarossa A, Massone M, Cichero E, Brullo C.   +5 more
europepmc   +1 more source