Results 241 to 250 of about 1,815,617 (316)

Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression. [PDF]

Blood Adv
Perfetto M, Danoff A, Ishfaq M, Monroe H, Mohideen A, Chen M, Tejero J, Stratman AN, Okawa S, Yien YY.   +9 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

A deep learning approach for time-consistent cell cycle phase prediction from microscopy data. [PDF]

PLoS Comput Biol
Bonte T, Pourcelot O, Safieddine A, Slimani F, Mueller F, Weil D, Bertrand E, Walter T.   +7 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Cell Cycle Plasticity and Heterogeneity: An Underappreciated Feature of Cancer and Treatment Response. [PDF]

Cancer Heterog Plast
Knudsen ES, O'Connor TN, Witkiewicz AK.
europepmc   +1 more source

Structural and functional studies of the cell cycle regulator RGC-32

, 2017
Lina Chen
openalex  

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors. [PDF]

EMBO J
Bernadskaya YY, Kuan A, Tjärnberg A, Brandenburg J, Zhang P, Wiechecki K, Kaplan N, Failla M, Bikou M, Madilian O, Bruderer N, Wang W, Christiaen L.   +12 more
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Correction: Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway

Molecular Cancer
Joshua E Allen, Gabriel Krigsfeld, Luv Patel, Patrick A Mayes, David T Dicker, Gen Sheng Wu, Wafik S El-Deiry   +6 more
doaj   +1 more source