Results 251 to 260 of about 16,449,484 (363)

OLFML2A mediates cell cycle regulation in triple-negative breast cancer via EZH2. [PDF]

Front Oncol
Ding H, Chen Y, Yu Q, Jiang W, Gao X.
europepmc   +1 more source

Cell-Cycle Therapeutics Come of Age.

Journal of Clinical Oncology, 2017
M. Ingham, G. Schwartz
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

H2valdien3 arrests the cell cycle and induces apoptosis of gastric cancer. [PDF]

Open Med (Wars)
Dang C, Ma S, Zhao X, Wang R, Liu R, Li H.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

FuChi: A cell cycle biosensor for investigating cell-cycle kinetics during avian development

Sudderick ZR, Briggs T, Mubarak S, Van Kerckvoorde M, Hernandez-Rodriguez AR, Panda SK, Riddell J, Batho-Samblas C, Taylor L, McTeir L, Meunier D, Findlay A, Roberts F, Raper A, Sakaue-Sawano A, Miyawaki A, Rainger J, Schoenebeck JJ, Weijer CJ, McGrew MJ, Headon DJ, Davey MG, Mort RL, Glover JD.   +23 more
europepmc   +1 more source

The Interaction of <i>CircESR1</i> and HNRNPAB Regulates Cell Cycle Transition of Breast Cancer Cell. [PDF]

Int J Biol Sci
Xu J, Xu Q, Cao T, Wang M, Shang Y, Tang J, Wu S, Ma X, Han X, Lobie PE, Qian L, Zhu T.   +11 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CDC26 facilitates ferroptosis through SLC7A11 degradation and cell cycle arrest. [PDF]

Clin Exp Med
Lin J, Chen F, Tang H, Cai X, Huang M, Liang R, Kang R, Tang D, Liu J.   +8 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source