Results 301 to 310 of about 16,449,484 (363)
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Science, 1996
Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly regulate their cell cycles. Genetic alterations affecting p16 INK4a and cyclin D1, proteins that govern phosphorylation of the retinoblastoma protein (RB) and ...
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Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically acquired damage to genes that directly regulate their cell cycles. Genetic alterations affecting p16 INK4a and cyclin D1, proteins that govern phosphorylation of the retinoblastoma protein (RB) and ...
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New England Journal of Medicine, 1981
FIFTEEN years ago it seemed that one could selectively damage cancer cells by exploiting simple differences in the cell-cycle kinetics of normal and neoplastic cells.
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FIFTEEN years ago it seemed that one could selectively damage cancer cells by exploiting simple differences in the cell-cycle kinetics of normal and neoplastic cells.
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Blood Reviews, 1991
Over the past few years there has been a resurgance of interest in the cell cycle. The excitement has mainly been due to the fact that researchers all over the world who had been working on seemingly different processes in yeast, fruit flies, frogs and man have found that many of the processes and individual proteins have been highly conserved.
A, Bybee, N S, Thomas
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Over the past few years there has been a resurgance of interest in the cell cycle. The excitement has mainly been due to the fact that researchers all over the world who had been working on seemingly different processes in yeast, fruit flies, frogs and man have found that many of the processes and individual proteins have been highly conserved.
A, Bybee, N S, Thomas
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2002
The cell cycle is the sequence of events through which a cell duplicates its genome, grows, and divides. Major cell cycle transitions are driven by cyclin-dependent kinases and other kinases. Ubiquitin-mediated protein degradation is also a major driving force for cell cycle transitions.
V J, Tannoch, P W, Hinds, L H, Tsai
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The cell cycle is the sequence of events through which a cell duplicates its genome, grows, and divides. Major cell cycle transitions are driven by cyclin-dependent kinases and other kinases. Ubiquitin-mediated protein degradation is also a major driving force for cell cycle transitions.
V J, Tannoch, P W, Hinds, L H, Tsai
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Current Opinion in Cell Biology, 1994
Checkpoints help ensure that cell cycle events occur in the correct order. Studies on mammalian cells identified inhibitors of complexes of cyclins and cyclin-dependent kinases as components of cell cycle checkpoints and provide the first glimpse of the molecular pathways that prevent cells with damaged DNA from replicating their DNA.
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Checkpoints help ensure that cell cycle events occur in the correct order. Studies on mammalian cells identified inhibitors of complexes of cyclins and cyclin-dependent kinases as components of cell cycle checkpoints and provide the first glimpse of the molecular pathways that prevent cells with damaged DNA from replicating their DNA.
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What cycles the cell? -Robust autonomous cell cycle models
Mathematical Medicine and Biology, 2009The cell cycle is one of the best studied cellular mechanisms at the experimental and theoretical levels. Although most of the important biochemical components and reactions of the cell cycle are probably known, the precise way the cell cycle dynamics are driven is still under debate.
Orit, Lavi, Yoram, Louzoun
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Trends in Genetics, 1988
Abstract One of the most exciting aspects of scientific research is the convergence of several apparently quite diverse types of investigation. Such events are rare, and the resulting cross-fertilization demands that findings derived from different areas are substantially reassessed.
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Abstract One of the most exciting aspects of scientific research is the convergence of several apparently quite diverse types of investigation. Such events are rare, and the resulting cross-fertilization demands that findings derived from different areas are substantially reassessed.
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Nature reviews. Molecular cell biology, 2021
Helen K. Matthews +2 more
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Helen K. Matthews +2 more
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Methods in Cell Science, 1999
The yeast Saccharomyces cerevisiae has been an excellent model system for cell cycle studies. Many such studies require cells synchronized in some particular portion of the cell cycle. Here, methods are described for obtaining and examining synchronized cells as they pass through one or more rounds of the cell cycle. The methods are of two types. First,
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The yeast Saccharomyces cerevisiae has been an excellent model system for cell cycle studies. Many such studies require cells synchronized in some particular portion of the cell cycle. Here, methods are described for obtaining and examining synchronized cells as they pass through one or more rounds of the cell cycle. The methods are of two types. First,
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Cell Cycles in Cell Hierarchies
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1986In the replacing tissues of the body, namely the bone marrow, testis, and the surface epithelia with their appendages, cell replacement would appear to be achieved using an hierarchically organized proliferative compartment with relatively few ultimate stem cells producing dividing transit cells which eventually differentiate and mature into the ...
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