Results 101 to 110 of about 526,953 (308)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells [PDF]

, 2015
Breast cancer is one of the most common causes of cancer-related deaths in women. The estrogen receptor (ERα) is well known for having growth promoting effects in breast cancer.
Adema, G.J. (Gosse), Ansems, M. (Marleen), de Graaf, A.M.A. (Annemarie M. A.), Foekens, J.A. (John), Looman, M.W.G. (Maaike W. G.), Martens, J.W.M. (John), Sieuwerts, A.M. (Anieta), Smid, M. (Marcel), Søndergaard, J.N. (Jonas Nørskov), Weerd, V. (Vanja) de, Zuidscherwoude, M. (Malou)   +10 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Targeting Polo-like kinase 1 and TRAIL enhances apoptosis in non-small cell lung cancer [PDF]

, 2018
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in cancer cells without causing damage to normal cells.
De Grève, Jacques, De Vlieghere, Elly, De Wever, Olivier, Giron, Philipe, Kronenberger, Peter, Noor, Alfiah, Teugels, Erik, Umelo, Ijeoma Adaku   +7 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

PPAR-alpha: a novel target in pancreatic cancer [PDF]

, 2015
Background: Current targeted therapies in pancreatic cancer have been ineffective. The tumor stroma, including intra- and peri-tumoral inflammation and fibrosis, is increasingly implicated in pancreatic cancer.
Hua, Alexander Mach
core   +1 more source

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle [PDF]

, 2014
The basic machinery that detects DNA damage is the same throughout the cell cycle. Here, we show, in contrast, that reversal of DNA damage responses (DDRs) and recovery are fundamentally different in G1 and G2 phases of the cell cycle.
A. T. Saurin, Agarwal, Chang, Choi, Chowdhury, Ciccia, Crawford, D. Chowdhury, Deng, E. E. Voest, Falk, Fiscella, Fujimoto, G. J. P. L. Kops, Gomes, Harper, Harrison, I. A. Shaltiel, Katayose, Kuerbitz, Lee, Lindqvist, Liu, Lu, Lukas, Lyu, M. Aprelia, Macurek, Matsuoka, R. H. Medema, Raman, Rauta, Reinhardt, Reinhardt, Sakaue-Sawano, Shreeram, Sousa-Nunes, Takekawa, Wang   +38 more
core   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Acetylation of Chromatin-Associated Histone H3 Lysine 56 Inhibits the Development of Encysted Artemia Embryos.

PLoS ONE, 2013
BackgroundAs a response to harsh environments, the crustacean artemia produces diapause gastrula embryos (cysts), in which cell division and embryonic development are totally arrested.
Rong Zhou, Fan Yang, Dian-Fu Chen, Yu-Xia Sun, Jin-Shu Yang, Wei-Jun Yang   +5 more
doaj   +1 more source

Quantitative Proteomics Reveals a "Poised Quiescence" Cellular State after Triggering the DNA Replication Origin Activation Checkpoint [PDF]

, 2010
An origin activation checkpoint has recently been discovered in the G1 phase of the mitotic cell cycle, which can be triggered by loss of DNA replication initiation factors such as the Cdc7 kinase.
Crawford, M, Godovac-Zimmermann, J, Mulvey, C, Stoeber, K, Tudzarova, S, Williams, GH   +5 more
core   +1 more source