The G2 checkpoint activated by DNA damage does not prevent genome instability in plant cells [PDF]
, 2006 Root growth, G2 length, and the frequency of aberrant mitoses and apoptotic nuclei were recorded after a single X-ray irradiation, ranging from 2.5 to 40 Gy, in Allium cepa L. root meristematic cells.
Carballo, Jesús A +2 more
core +4 more sources
Signalling cell cycle arrest and cell death through the MMR System [PDF]
, 2006 Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core +1 more source
Modulations of cell cycle checkpoints during HCV associated disease
BMC Infectious Diseases, 2009 Background Impaired proliferation of hepatocytes has been reported in chronic Hepatitis C virus infection. Considering the fundamental role played by cell cycle proteins in controlling cell proliferation, altered regulation of these proteins could ...
Jafri Wasim +4 more
doaj +1 more source
Probing Mammalian Cell Size Homeostasis by Channel-Assisted Cell Reshaping
Cell Reports, 2017 Cell size homeostasis can be achieved by size checkpoints that couple cell size to cell-cycle progression or by alternative mechanisms such as constant extension.
Giulia Varsano, Yuedi Wang, Min Wu
doaj +1 more source
Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us [PDF]
, 2009 The DNA damage response (DDR) mechanisms represent a vital line of defense against exogenous and endogenous DNA damage to enhance two distinct outcomes, survival and the maintenance of genomic stability. The latter is critical for cancer avoidance.
Jeggo, Peggy A.
core +2 more sources
The potential role and application of PARP inhibitors in cancer treatment [PDF]
, 2009 Background: Since many anti-cancer agents act by inflicting DNA damage on tumour cells, there is increasing interest in the use of inhibitors of DNA repair to increase the cytotoxicity of these agents.
Chalmers, Anthony J
core +2 more sources
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing [PDF]
, 2001 Checkpoints maintain order and fidelity in the cell cycle by blocking late-occurring events when earlier events are improperly executed. Here we describe evidence for the participation of Chk1 in an intra-S phase checkpoint in mammalian cells.
Feijoo, Carmen +6 more
core +2 more sources
Cell Cycle Regulation by Checkpoints [PDF]
, 2014 Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis. Many of these mechanisms are ancient in origin and highly conserved, and
Kevin J, Barnum, Matthew J, O'Connell
openaire +2 more sources
Deubiquitinating Enzyme: A Potential Secondary Checkpoint of Cancer Immunity
Frontiers in Oncology, 2020 The efficacy of cancer immunotherapy depends on the fine interplay between tumoral immune checkpoints and host immune system. However, the up-to-date clinical performance of checkpoint blockers in cancer therapy revealed that higher-level regulation ...
Xing Huang +26 more
doaj +1 more source
Possible attenuation of the G2 DNA damage cell cycle checkpoint in HeLa cells by extremely low frequency (ELF) electromagnetic fields [PDF]
, 2002 BACKGROUND: The issue remains unresolved as to whether low frequency magnetic fields can affect cell behaviour, with the possibility that they may be in part responsible for the increased incidence of leukaemia in parts of the population exposed to ...
Harris, Paul A. +3 more
core +3 more sources