The synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment [PDF]
Journal of Hematology & Oncology, 2022 Continuous cell division is a hallmark of cancer, and the underlying mechanism is tumor genomics instability. Cell cycle checkpoints are critical for enabling an orderly cell cycle and maintaining genome stability during cell division.
Shuangying Li +5 more
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Immune Landscape and Classification in Lung Adenocarcinoma Based on a Novel Cell Cycle Checkpoints Related Signature for Predicting Prognosis and Therapeutic Response [PDF]
Frontiers in Genetics, 2022 Lung adenocarcinoma (LUAD) is one of the most common malignancies with the highest mortality globally, and it has a poor prognosis. Cell cycle checkpoints play a central role in the entire system of monitoring cell cycle processes, by regulating the ...
Jian Yang +21 more
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Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle. [PDF]
PLoS ONE, 2013 In multicellular organisms, cell division is regulated by growth factors (GFs). In the absence of GFs, cells exit the cell cycle at a site in G1 referred to as the restriction point (R) and enter a state of quiescence known as G0.
Mahesh Saqcena +5 more
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Defective cell cycle checkpoints as targets for anti-cancer therapies [PDF]
Frontiers in Pharmacology, 2012 Conventional chemotherapeutics target the proliferating fraction of cells, which will include the tumour cells, but are also toxic to actively proliferating normal tissues.
Brian eGabrielli +2 more
doaj +2 more sources
Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication. [PDF]
PLoS Pathogens, 2016 Kaposi's sarcoma herpesvirus (KSHV) causes Kaposi's sarcoma and certain lymphoproliferative malignancies. Latent infection is established in the majority of tumor cells, whereas lytic replication is reactivated in a small fraction of cells, which is ...
Giuseppe Balistreri +19 more
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Dose dependent effects on cell cycle checkpoints and DNA repair by bendamustine. [PDF]
PLoS ONE, 2012 Bendamustine (BDM) is an active chemotherapeutic agent approved in the U. S. for treating chronic lymphocytic leukemia and non-Hodgkin lymphoma. Its chemical structure suggests it may have alkylator and anti-metabolite activities; however the precise ...
Neil Beeharry +4 more
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Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints. [PDF]
PLoS ONE, 2012 Replication stress- and DNA damage-induced cell cycle checkpoints are critical for maintaining genome stability. To identify protein phosphatases involved in the activation and maintenance of the checkpoints, we have carried out RNA interference-based ...
Yiu Huen Tsang +4 more
doaj +1 more source
The Role of chk2 in Response to DNA Damage in Cancer Cells [PDF]
Journal of Genetic Resources, 2015 Accumulation of gene changes and chromosomal instability in response to cellular DNA damage lead to cancer. DNA damage induces cell cycle checkpoints pathways.
Fereshteh Mir Mohammadrezaei
doaj +1 more source
Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects
Nature Communications, 2022 Progression of the canonical eukaryotic cell cycle is tightly regulated. While the cell cycle control of flagellated protozoa Trypanosoma brucei shares conserved features with other eukaryotes certain cell cycle checkpoints are absent.
Catarina A. Marques +4 more
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MK3 modulation affects BMI1-dependent and independent cell cycle check-points. [PDF]
PLoS ONE, 2015 Although the MK3 gene was originally found deleted in some cancers, it is highly expressed in others. The relevance of MK3 for oncogenesis is currently not clear. We recently reported that MK3 controls ERK activity via a negative feedback mechanism. This
Peggy Prickaerts +13 more
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