Results 31 to 40 of about 103,273 (243)
Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity. [PDF]
, 2020 Although immunotherapies have achieved remarkable salutary effects among subgroups of advanced cancers, most patients do not respond. We comprehensively evaluated biomarkers associated with the "cancer-immunity cycle" in the pan-cancer setting in order ...
Dressman, Devin +13 more
core +1 more source
Plasmodium falciparum CRK4 links early mitotic events to the onset of S-phase during schizogony
mBio, 2023 Plasmodium falciparum proliferates through schizogony in the clinically relevant blood stage of infection. During schizogony, consecutive rounds of DNA replication and nuclear division give rise to multinucleated stages before cellularization occurs ...
Marta Machado +4 more
doaj +1 more source
PP2ARts1 is a master regulator of pathways that control cell size [PDF]
, 2014 Cell size checkpoints ensure that passage through G1 and mitosis occurs only when sufficient growth has occurred. The mechanisms by which these checkpoints work are largely unknown.
Dephoure, Noah +8 more
core +1 more source
Molecular switch model for cardiomyocyte proliferation
Cell Regeneration, 2019 This review deals with the human adult cardiomyocyte proliferation as a potential source for heart repair after injury. The mechanism to regain the proliferative capacity of adult cardiomyocytes is a challenge.
Satwat Hashmi, H.R. Ahmad
doaj +1 more source
Journal of Biology, 2003 Background It is widely believed that cell-size checkpoints help to coordinate cell growth and cell-cycle progression, so that proliferating eukaryotic cells maintain their size.
Raff Martin, Conlon Ian
doaj +1 more source
Advances in Cancer Biology - Metastasis, 2021 Cancer treatment is an economic burden because of the very expensive drugs which depend on improvement in modern technology. Furthermore, the rate of success of cancer treatments is not actually satisfying.
Aritra Kumar Dan +6 more
doaj +1 more source
Ataxia-Telangiectasia Mutated and the Mre11-Rad50-NBS1 Complex:Promising Targets for Radiosensitization [PDF]
, 2012 Radiotherapy plays a central part in cancer treatment, and use of radiosensitizing agents can greatly enhance this modality. Although studies have shown that several chemotherapeutic agents have the potential to increase the radiosensitivity of tumor ...
Fujiwara, Toshiyoshi +2 more
core +1 more source
Molecular mechanisms creating bistable switches at cell cycle transitions [PDF]
Open Biology, 2013 Progression through the eukaryotic cell cycle is characterized by specific transitions, where cells move irreversibly from stage i−1 of the cycle into stage i. These irreversible cell cycle transitions are regulated by underlying bistable switches, which
Anael Verdugo +3 more
doaj +1 more source
PLoS Biology, 2010 DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance.
Marcel A T M van Vugt +15 more
doaj +1 more source
DNA damage stress: Cui prodest? [PDF]
, 2019 DNA is an entity shielded by mechanisms that maintain genomic stability and are essential for living cells; however, DNA is constantly subject to assaults from the environment throughout the cellular life span, making the genome susceptible to mutation ...
Cialfi, Samantha +5 more
core +1 more source