Results 31 to 40 of about 6,549,693 (278)

Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]

, 2014
Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Jaiswal, H., Mullers, E, Cascales, H.S., Cascales, HS, Lindqvist, A., Jaiswal, H, Saurin, AT, Lindqvist, A,, Müllers, E., Saurin, A.T.; id_orcid   +9 more
core   +1 more source

Can eukaryotic cells monitor the presence of unreplicated DNA?

Cell Division, 2007
Completion of DNA replication before mitosis is essential for genome stability and cell viability. Cellular controls called checkpoints act as surveillance mechanisms capable of detecting errors and blocking cell cycle progression to allow time for those
Aragón Luis, De Piccoli Giacomo, Torres-Rosell Jordi   +2 more
doaj   +1 more source

Deubiquitinating Enzyme: A Potential Secondary Checkpoint of Cancer Immunity

Frontiers in Oncology, 2020
The efficacy of cancer immunotherapy depends on the fine interplay between tumoral immune checkpoints and host immune system. However, the up-to-date clinical performance of checkpoint blockers in cancer therapy revealed that higher-level regulation ...
Xing Huang, Xing Huang, Xing Huang, Xiaozhen Zhang, Xiaozhen Zhang, Xiaozhen Zhang, Jian Xu, Jian Xu, Jian Xu, Xun Wang, Xun Wang, Xun Wang, Gang Zhang, Gang Zhang, Gang Zhang, Tianyu Tang, Tianyu Tang, Tianyu Tang, Xiaochao Shen, Xiaochao Shen, Xiaochao Shen, Tingbo Liang, Tingbo Liang, Tingbo Liang, Xueli Bai, Xueli Bai, Xueli Bai   +26 more
doaj   +1 more source

Cell Cycle Checkpoints in Cancer Therapy: A Review

Al-SalamJournal for Medical Science
DNA replication, repair, and cell division are controlled by cell-cycle checkpoints to maintain genomic integrity. To survive replication and oncogenic stress, cancer cells selectively lower checkpoint barriers while preserving others.
Shamsalmiluk Mohammed Abdulghani, Khalid Suhail A. Alazzawi, Marwa Adel Hussein, Asmaa A. Jawad   +3 more
doaj   +1 more source

Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

Cell Reports, 2019
Summary: Triple-negative breast cancers (TNBCs) display great diversity in cisplatin sensitivity that cannot be explained solely by cancer-associated DNA repair defects.
Anne Margriet Heijink, Marieke Everts, Megan E. Honeywell, Ryan Richards, Yannick P. Kok, Elisabeth G.E. de Vries, Michael J. Lee, Marcel A.T.M. van Vugt   +7 more
doaj   +1 more source

A drift-diffusion checkpoint model predicts a highly variable and growth-factor-sensitive portion of the cell cycle G1 phase. [PDF]

PLoS ONE, 2018
Even among isogenic cells, the time to progress through the cell cycle, or the intermitotic time (IMT), is highly variable. This variability has been a topic of research for several decades and numerous mathematical models have been proposed to explain ...
Zack W Jones, Rachel Leander, Vito Quaranta, Leonard A Harris, Darren R Tyson   +4 more
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Expression of cdk4 and p16 in Oral Lichen Planus

eJournal of Oral Maxillofacial Research, 2015
Objectives: The purpose of this study was to evaluate the expression of cdk4 and p16, the proteins implicated in hyperproliferation and arrest in oral lichen planus and to compare their expression in erosive and non-erosive oral lichen planus and with ...
Sinny Goel, Nita Khurana, Akanksha Marvah, Sunita Gupta   +3 more
doaj   +1 more source

Effects of seawater acidification on cell cycle control mechanisms in Strongylocentrotus purpuratus embryos. [PDF]

PLoS ONE, 2012
Previous studies have shown fertilization and development of marine species can be significantly inhibited when the pH of sea water is artificially lowered.
Sean P Place, Bryan W Smith
doaj   +1 more source