Results 41 to 50 of about 103,273 (243)
Evolutionary Divergence in DNA Damage Responses among Fungi
mBio, 2021 Cell cycle checkpoints and DNA repair pathways contribute to maintaining genome integrity and are thought to be evolutionarily ancient and broadly conserved.
Jacob L. Steenwyk
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Cell Reports, 2019 Summary: Triple-negative breast cancers (TNBCs) display great diversity in cisplatin sensitivity that cannot be explained solely by cancer-associated DNA repair defects.
Anne Margriet Heijink +7 more
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A drift-diffusion checkpoint model predicts a highly variable and growth-factor-sensitive portion of the cell cycle G1 phase. [PDF]
PLoS ONE, 2018 Even among isogenic cells, the time to progress through the cell cycle, or the intermitotic time (IMT), is highly variable. This variability has been a topic of research for several decades and numerous mathematical models have been proposed to explain ...
Zack W Jones +4 more
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Cell cycle checkpoint control [PDF]
Experimental & Molecular Medicine, 1997 Genetic instability is considered to be a major driving force of malignancy of cancer cells, and at least some of cancer-associated genetic instability is known to be caused by defects in the cell cycle checkpoint control. Patients of the cancer-prone genetic disorder ataxia telangiectagia frequently develop malignant lymphoma and their cells are ...
Hiroshi Murakami, Hiroto Okayama
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Expression of cdk4 and p16 in Oral Lichen Planus
eJournal of Oral Maxillofacial Research, 2015 Objectives: The purpose of this study was to evaluate the expression of cdk4 and p16, the proteins implicated in hyperproliferation and arrest in oral lichen planus and to compare their expression in erosive and non-erosive oral lichen planus and with ...
Sinny Goel +3 more
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Effects of seawater acidification on cell cycle control mechanisms in Strongylocentrotus purpuratus embryos. [PDF]
PLoS ONE, 2012 Previous studies have shown fertilization and development of marine species can be significantly inhibited when the pH of sea water is artificially lowered.
Sean P Place, Bryan W Smith
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Modulation of gene expression in endothelial cells in response to high LET nickel ion irradiation [PDF]
, 2014 Ionizing radiation can elicit harmful effects on the cardiovascular system at high doses. Endothelial cells are critical targets in radiation-induced cardiovascular damage.
Aerts, An +15 more
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Adaptive changes in the DNA damage response during skeletal muscle cell differentiation
Frontiers in Cell and Developmental Biology, 2023 DNA double-strand breaks (DSBs) trigger specialized cellular mechanisms that collectively form the DNA damage response (DDR). In proliferating cells, the DDR serves the function of mending DNA breaks and satisfying the cell-cycle checkpoints.
Inês Faleiro +6 more
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Understanding the limitations of radiation-induced cell cycle checkpoints. [PDF]
Crit Rev Biochem Mol Biol, 2011 Deckbar D, Jeggo PA, Löbrich M.
europepmc +2 more sources