Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints. [PDF]
PLoS ONE, 2012 Replication stress- and DNA damage-induced cell cycle checkpoints are critical for maintaining genome stability. To identify protein phosphatases involved in the activation and maintenance of the checkpoints, we have carried out RNA interference-based ...
Yiu Huen Tsang +4 more
doaj +1 more source
The Role of chk2 in Response to DNA Damage in Cancer Cells [PDF]
Journal of Genetic Resources, 2015 Accumulation of gene changes and chromosomal instability in response to cellular DNA damage lead to cancer. DNA damage induces cell cycle checkpoints pathways.
Fereshteh Mir Mohammadrezaei
doaj +1 more source
Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects
Nature Communications, 2022 Progression of the canonical eukaryotic cell cycle is tightly regulated. While the cell cycle control of flagellated protozoa Trypanosoma brucei shares conserved features with other eukaryotes certain cell cycle checkpoints are absent.
Catarina A. Marques +4 more
doaj +1 more source
Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D. [PDF]
BMC Cancer, 2013 Laurent J +5 more
europepmc +3 more sources
A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy. [PDF]
Cancer Cell, 2015 Cannell IG +9 more
europepmc +2 more sources
MK3 modulation affects BMI1-dependent and independent cell cycle check-points. [PDF]
PLoS ONE, 2015 Although the MK3 gene was originally found deleted in some cancers, it is highly expressed in others. The relevance of MK3 for oncogenesis is currently not clear. We recently reported that MK3 controls ERK activity via a negative feedback mechanism. This
Peggy Prickaerts +13 more
doaj +1 more source
Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword [PDF]
, 2016 Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation.
DELLA MONICA, ROSA +2 more
core +1 more source
Cell cycle checkpoints: methods and protocols
European Journal of Histochemistry, 2012 As it is well known at the end of each cell cycle step there are checkpoints to verify that DNA duplication and segregation (among other events) met every requirements before the cell is allowed to proceed to the next step.
Carlo Alberto Redi
doaj +1 more source
Analysis of Checkpoint Responses to Histone Deacetylase Inhibitors [PDF]
, 2004 Cell cycle checkpoints respond to a wide range of stresses to prevent compromise to the integrity of the cell. The best studied checkpoints are those induced by genotoxic agents that cause DNA damage.
Beamish, Heather +2 more
core +1 more source
Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements [PDF]
, 2015 Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability.
A Janssen +39 more
core +1 more source