The synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment [PDF]
Journal of Hematology & Oncology, 2022 Continuous cell division is a hallmark of cancer, and the underlying mechanism is tumor genomics instability. Cell cycle checkpoints are critical for enabling an orderly cell cycle and maintaining genome stability during cell division.
Shuangying Li +5 more
doaj +3 more sources
Immune Landscape and Classification in Lung Adenocarcinoma Based on a Novel Cell Cycle Checkpoints Related Signature for Predicting Prognosis and Therapeutic Response [PDF]
Frontiers in Genetics, 2022 Lung adenocarcinoma (LUAD) is one of the most common malignancies with the highest mortality globally, and it has a poor prognosis. Cell cycle checkpoints play a central role in the entire system of monitoring cell cycle processes, by regulating the ...
Jian Yang +21 more
doaj +2 more sources
Can eukaryotic cells monitor the presence of unreplicated DNA? [PDF]
Cell Division, 2007 Completion of DNA replication before mitosis is essential for genome stability and cell viability. Cellular controls called checkpoints act as surveillance mechanisms capable of detecting errors and blocking cell cycle progression to allow time for those
Aragón Luis +2 more
doaj +4 more sources
Defective cell cycle checkpoints as targets for anti-cancer therapies [PDF]
Frontiers in Pharmacology, 2012 Conventional chemotherapeutics target the proliferating fraction of cells, which will include the tumour cells, but are also toxic to actively proliferating normal tissues.
Brian eGabrielli +2 more
doaj +2 more sources
Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor. [PDF]
PLoS ONE, 2010 Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the
Andrew J Massey +5 more
doaj +3 more sources
Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention. [PDF]
Cells, 2020 Cholangiocarcinoma (CCA) is an aggressive group of biliary tract cancers, characterized by late diagnosis, low effective chemotherapies, multidrug resistance, and poor outcomes.
Di Sotto A +8 more
europepmc +3 more sources
Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication. [PDF]
PLoS Pathogens, 2016 Kaposi's sarcoma herpesvirus (KSHV) causes Kaposi's sarcoma and certain lymphoproliferative malignancies. Latent infection is established in the majority of tumor cells, whereas lytic replication is reactivated in a small fraction of cells, which is ...
Giuseppe Balistreri +19 more
doaj +2 more sources
Dose dependent effects on cell cycle checkpoints and DNA repair by bendamustine. [PDF]
PLoS ONE, 2012 Bendamustine (BDM) is an active chemotherapeutic agent approved in the U. S. for treating chronic lymphocytic leukemia and non-Hodgkin lymphoma. Its chemical structure suggests it may have alkylator and anti-metabolite activities; however the precise ...
Neil Beeharry +4 more
doaj +2 more sources
Integrative analysis of gene alterations and immunoexpression profiles of cell cycle checkpoints in oral squamous cell carcinoma. [PDF]
Cancer Biomark, 2020 Pérez-Sayáns M +6 more
europepmc +3 more sources
Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle. [PDF]
PLoS ONE, 2013 In multicellular organisms, cell division is regulated by growth factors (GFs). In the absence of GFs, cells exit the cell cycle at a site in G1 referred to as the restriction point (R) and enter a state of quiescence known as G0.
Mahesh Saqcena +5 more
doaj +1 more source