Cell cycle checkpoints: methods and protocols
European Journal of Histochemistry, 2012 As it is well known at the end of each cell cycle step there are checkpoints to verify that DNA duplication and segregation (among other events) met every requirements before the cell is allowed to proceed to the next step.
Carlo Alberto Redi
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Cell cycle checkpoints in Caenorhabditis elegans: the 14-3-3 gene par-5 is required for germline development and DNA damage response / Checkpoints del ciclo celular en Caenorhabditis elegans: el gen 14-3-3, par-5, es necesario para el desarrollo y respuesta al daño genómico de la línea germinal [PDF]
, 2012 [eng] 14-3-3 proteins have been extensively studied from yeast to mammals, and are associated with multiple roles ranging from fundamental processes such as cell cycle, apoptosis and stress response to diseases such as neurodegeneration and cancer ...
Aristizábal Corrales, David
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Cell Cycle Regulation by Checkpoints [PDF]
, 2014 Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis. Many of these mechanisms are ancient in origin and highly conserved, and
Kevin J, Barnum, Matthew J, O'Connell
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Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses. [PDF]
, 1998 Eukaryotic cells respond to DNA damage and S phase replication blocks by arresting cell-cycle progression through the DNA structure checkpoint pathways.
Lindsay, Howard D. +6 more
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Transcriptome changes and cAMP oscillations in an archaeal cell cycle [PDF]
, 2007 Background The cell cycle of all organisms includes mass increase by a factor of two, replication of the genetic material, segregation of the genome to different parts of the cell, and cell division into two daughter cells.
Jörg Soppa +8 more
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Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor. [PDF]
PLoS ONE, 2010 Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the
Andrew J Massey +5 more
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Molecular switch model for cardiomyocyte proliferation
Cell Regeneration, 2019 This review deals with the human adult cardiomyocyte proliferation as a potential source for heart repair after injury. The mechanism to regain the proliferative capacity of adult cardiomyocytes is a challenge.
Satwat Hashmi, H.R. Ahmad
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Plasmodium falciparum CRK4 links early mitotic events to the onset of S-phase during schizogony
mBio, 2023 Plasmodium falciparum proliferates through schizogony in the clinically relevant blood stage of infection. During schizogony, consecutive rounds of DNA replication and nuclear division give rise to multinucleated stages before cellularization occurs ...
Marta Machado +4 more
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Journal of Biology, 2003 Background It is widely believed that cell-size checkpoints help to coordinate cell growth and cell-cycle progression, so that proliferating eukaryotic cells maintain their size.
Raff Martin, Conlon Ian
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Nek family of kinases in cell cycle, checkpoint control and cancer [PDF]
, 2011 Early studies in lower Eukaryotes have defined a role for the members of the NimA related kinase (Nek) family of protein kinases in cell cycle control. Expansion of the Nek family throughout evolution has been accompanied by their broader involvement in ...
Haider Nasir +15 more
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