Results 51 to 60 of about 6,549,693 (278)

The final checkpoint. Cancer as an adaptive evolutionary mechanism

Biotechnology & Biotechnological Equipment, 2016
The mechanisms for identification of DNA damage and repair usually manage DNA damage very efficiently. If damaged cells manage to bypass the checkpoints where the integrity of the genome is assessed and the decisions whether to proceed with the cell ...
Rumena Petkova, Stoyan Chakarov
doaj   +1 more source

Repair on the go: E. coli maintains a high proliferation rate while repairing a chronic DNA double-strand break. [PDF]

PLoS ONE, 2014
DNA damage checkpoints exist to promote cell survival and the faithful inheritance of genetic information. It is thought that one function of such checkpoints is to ensure that cell division does not occur before DNA damage is repaired.
Elise Darmon, John K Eykelenboom, Manuel A Lopez-Vernaza, Martin A White, David R F Leach   +4 more
doaj   +1 more source

Advances in the Current Understanding of How Low-Dose Radiation Affects the Cell Cycle

Cells, 2022
Cells exposed to ionizing radiation undergo a series of complex responses, including DNA damage, reproductive cell death, and altered proliferation states, which are all linked to cell cycle dynamics.
Md Gulam Musawwir Khan, Yi Wang
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A checkpoint-oriented cell cycle simulation model [PDF]

Cell Cycle, 2019
Modeling and in silico simulations are of major conceptual and applicative interest in studying the cell cycle and proliferation in eukaryotic cells. In this paper, we present a cell cycle checkpoint-oriented simulator that uses agent-based simulation modeling to reproduce the dynamics of a cancer cell population in exponential growth.
Bernard, David, Mondésert, Odile, Gomes, Aurélie, Duthen, Yves, Lobjois, Valérie, Cussat-Blanc, Sylvain, Ducommun, Bernard   +6 more
openaire   +4 more sources

ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair [PDF]

, 2008
Background: The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum-drug resistance. Resistance was not associated with increased cellular glutathione or decreased accumulation of platinum, rather the resistant cell lines have a cell
Davey, Ross, Stordal, Britta, Stordal, B., Davey, R.   +3 more
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer

The EMBO Journal
Prolonged mitosis results in the destruction of MDM2, initiating a p53-dependent G1 cell-cycle arrest in the absence of DNA damage. Here, we investigate how DNA damage earlier in the cell cycle affects this mitotic-timer response.
Tomoaki Sobajima, Luke J Fulcher, Caleb Batley, Susanna J Alsop, Jonah Veakins, Francis A Barr   +5 more
doaj   +1 more source

Cell cycle: Checkpoint proteins and kinetochores [PDF]

Current Biology, 1997
Vertebrate homologs of yeast spindle assembly checkpoint proteins are localized to kinetochores and may act as a sensor for proper chromosome attachment to the mitotic spindle.
openaire   +2 more sources