Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox [PDF]
, 2020 To ward off against the catastrophic consequences of persistent DNA double-strand breaks (DSBs), eukaryotic cells have developed a set of complex signaling networks that detect these DNA lesions, orchestrate cell cycle checkpoints and ultimately lead to ...
Almeida, Sérgio F. de +3 more
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Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition. [PDF]
, 2010 The protein kinase Aurora-A is a major regulator of the cell cycle that orchestrates mitotic entry and is required for the assembly of a functional mitotic spindle.
Afshan McCarthy +9 more
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Cell cycle regulation and hematologic malignancies
Blood Science, 2019 . A complex network precisely regulates the cell cycle through the G1, S, G2, and M phases and is the basis for cell division under physiological and pathological conditions.
Yun Dai +3 more
doaj +1 more source
Genetic Requirements for Intra-Chromosomal Deletions [PDF]
, 2020 Chromosomal deletions are one of the most dangerous types of DNA damage and often arise as a result of inappropriately repaired DNA double strand breaks (DSB).
McPherson, Matthew
core
Targeting ATM pathway for therapeutic intervention in cancer [PDF]
, 2012 The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Chakarov, Stoyan +4 more
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The final checkpoint. Cancer as an adaptive evolutionary mechanism
Biotechnology & Biotechnological Equipment, 2016 The mechanisms for identification of DNA damage and repair usually manage DNA damage very efficiently. If damaged cells manage to bypass the checkpoints where the integrity of the genome is assessed and the decisions whether to proceed with the cell ...
Rumena Petkova, Stoyan Chakarov
doaj +1 more source
Repair on the go: E. coli maintains a high proliferation rate while repairing a chronic DNA double-strand break. [PDF]
PLoS ONE, 2014 DNA damage checkpoints exist to promote cell survival and the faithful inheritance of genetic information. It is thought that one function of such checkpoints is to ensure that cell division does not occur before DNA damage is repaired.
Elise Darmon +4 more
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Advances in the Current Understanding of How Low-Dose Radiation Affects the Cell Cycle
Cells, 2022 Cells exposed to ionizing radiation undergo a series of complex responses, including DNA damage, reproductive cell death, and altered proliferation states, which are all linked to cell cycle dynamics.
Md Gulam Musawwir Khan, Yi Wang
doaj +1 more source
, 2005 A major goal of modern computational biology is to simulate the collective behaviour of large cell populations starting from the intricate web of molecular interactions occurring at the microscopic level.
Airley R +26 more
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Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells. [PDF]
, 2015 Tyrosine kinase inhibitors (TKIs) including axitinib have been introduced in the treatment of renal cell carcinoma (RCC) because of their anti-angiogenic properties.
Amantini, C +6 more
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