Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses [PDF]
, 2023 Liyan Sui +9 more
openalex +1 more source
bir1 deletion causes malfunction of the spindle assembly checkpoint and apoptosis in yeast
Frontiers in Oncology, 2012 Cell division in yeast is a highly regulated and well studied event. Various checkpoints are placed throughout the cell cycle to ensure faithful segregation of sister chromatids.
Qun eRen +5 more
doaj +1 more source
Comparison of Perron and Floquet eigenvalues in age structured cell division cycle models [PDF]
, 2008 We study the growth rate of a cell population that follows an age-structured PDE with time-periodic coefficients. Our motivation comes from the comparison between experimental tumor growth curves in mice endowed with intact or disrupted circadian clocks,
Arino +12 more
core +6 more sources
Entwicklung und Validierung eines Bioassays zum Nachweis induzierter Genaktivität für den Einsatz auf der Internationalen Raumstation [PDF]
, 2007 Neben der fehlenden Schwerkraft stellt die Strahlenbelastung des Astronauten einen limitierenden Faktor für den Langzeitaufenthalt des Menschen im Weltraum dar.
Arenz, Andrea
core
Suppression of NBS1 Upregulates CyclinB to Induce Olaparib Sensitivity in Ovarian Cancer
Technology in Cancer Research & TreatmentBackground: Deficiencies in DNA damage repair responses promote chemotherapy sensitivity of tumor cells. The Nibrin homolog encoding gene Nijmegen Breakage Syndrome 1 (NBS1) is a crucial component of the MRE11-RAD50-NBN complex (MRN complex) and is ...
Ailing Zhong MMed +3 more
doaj +1 more source
Breaking Bad:How Viruses Subvert the Cell Cycle [PDF]
, 2018 Interactions between the host and viruses during the course of their co-evolution have not only shaped cellular function and the immune system, but also the counter measures employed by viruses.
Roberto Bruzzone +5 more
core +3 more sources
Immortalization-Upregulated Protein Promotes Pancreatic Cancer Progression By Regulating NPM1/FHL1-Mediated Cell-Cycle-Checkpoint Protein Activity [PDF]
, 2021 Qiankun Luo +10 more
openalex +1 more source
Cell Cycle and Cell Size Dependent Gene Expression Reveals Distinct Subpopulations at Single-Cell Level [PDF]
, 2017 Cell proliferation includes a series of events that is tightly regulated by several checkpoints and layers of control mechanisms. Most studies have been performed on large cell populations, but detailed understanding of cell dynamics and heterogeneity ...
Anders Ståhlberg +8 more
core +2 more sources
Breast Cancer Research, 2019 Background Breast cancer is the most common cancer to affect women and one of the leading causes of cancer-related deaths. Proper regulation of cell cycle checkpoints plays a critical role in preventing the accumulation of deleterious mutations ...
Bre-Anne Fifield +4 more
doaj +1 more source
Natural Product Communications, 2017 This study focuses on the comparative in vitro cytotoxicity of chelidonine and homochelidonine on human cancer and non-cancer cells. Both alkaloids produced a decrease in cellular growth in a dose-dependent manner exhibiting greater potency in cancer ...
Radim Havelek +5 more
doaj +1 more source