Results 91 to 100 of about 6,549,693 (278)

Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival

International Journal of Biological Sciences, 2009
The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the process of differentiation and cell death has grown considerably in the recent ...
Tina M. Thornton, Mercedes Rincon
doaj  

Transcriptomic correlates of cell cycle checkpoints with distinct prognosis, molecular characteristics, immunological regulation, and therapeutic response in colorectal adenocarcinoma. [PDF]

Front Immunol, 2023
Wang H, Wang W, Wang Z, Li X.
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells [PDF]

, 2003
In view of the common regulatory mechanism that induces transcription of tie mitotic phosphatase cdc25C and cyclin A at the beginning of S-phase, we investigated whether cdc25C was required for S-phase transit.
Patric Turowski, Franckhauser, Céline, Ned J. C. Lamb, Lamb, Ned,, Celine Franckhauser, Fernandez, A, Lamb, NJC, Turowski, P, Fernandez, Anne, Turowski, Patric, Morris, May, Franckhauser, C, Vaglio, P, Vaglio, Philippe, Morris, MC, Lamb, Ned, J., Anne Fernandez, May C. Morris, Anne Fern, Philippe Vaglio   +19 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

DUBbing cancer: Deubiquitylating enzymes involved in epigenetics, DNA damage and the cell cycle as therapeutic targets

Frontiers in Genetics, 2016
Controlling cell proliferation is one of the hallmarks of cancer. A number of critical checkpoints ascertain progression through the different stages of the cell cycle, which can be aborted when perturbed, for instance by errors in DNA replication and ...
Benedikt M Kessler, Adán Pinto Fernández   +1 more
doaj   +1 more source

Cell cycle checkpoints and beyond: Exploiting the ATR/CHK1/WEE1 pathway for the treatment of PARP inhibitor-resistant cancer. [PDF]

Pharmacol Res, 2022
Gupta N, Huang TT, Horibata S, Lee JM.
europepmc   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

PLK1 Induces Chromosomal Instability and Overrides Cell-Cycle Checkpoints to Drive Tumorigenesis. [PDF]

Cancer Res, 2021
Gheghiani L, Wang L, Zhang Y, Moore XTR, Zhang J, Smith SC, Tian Y, Wang L, Turner K, Jackson-Cook CK, Mukhopadhyay ND, Fu Z.   +11 more
europepmc   +1 more source

Regulation of the Bub2/Bfa1 GAP Complex by Cdc5 and Cell Cycle Checkpoints [PDF]

, 2001
During mitosis, a ras-related GTPase (Tem1) binds GTP and activates a signal transduction pathway to allow mitotic exit. During most of the cell cycle, Tem1 function is antagonized by a GTPase-activating protein complex, Bfa1/Bub2.
Elledge, Stephen J, Li, Yumei, Liu, Dou, Qin, Jun, Hu, Fenghua, Wang, Yanchang   +5 more
core   +1 more source