Results 81 to 90 of about 103,273 (243)
Cisplatinum and Taxol Induce Different Patterns of p53 Phosphorylation
Neoplasia: An International Journal for Oncology Research, 2001 Posttranslational modifications of p53 induced by two widely used anticancer agents, cisplatinum (DDP) and taxol were investigated in two human cancer cell lines.
Giovanna Damia +6 more
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Pds5A and Pds5B Display Non-redundant Functions in Mitosis and Their Loss Triggers Chk1 Activation
Frontiers in Cell and Developmental Biology, 2020 BackgroundPds5 is an abundant HEAT-repeat-containing protein that binds to cohesin and mediates sister chromatid cohesion. In vertebrates, Pds5A and Pds5B are known to protect DNA replication fork, as their loss leads to DNA damage.
Naif Al-Jomah +8 more
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Cell cycle: Checkpoint proteins and kinetochores [PDF]
Current Biology, 1997 Vertebrate homologs of yeast spindle assembly checkpoint proteins are localized to kinetochores and may act as a sensor for proper chromosome attachment to the mitotic spindle.
openaire +2 more sources
Oncogenic mutations produce similar phenotypes in Drosophila tissues of diverse origins
Biology Open, 2014 An emerging interest in oncology is to tailor treatment to particular cancer genotypes, i.e. oncogenic mutations present in the tumor, and not the tissue of cancer incidence.
Stefanie Stickel, Tin Tin Su
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Mutations In RAD27 Define A Potential Link Between G₁ Cyclins And DNA Replication [PDF]
, 1995 The yeast Saccharomyces cerevisiae has three G1 cyclin (CLN) genes with overlapping functions. To analyze the functions of the various CLN genes, we examined mutations that result in lethality in conjunction with loss of cln1 and cln2.
Cross, Frederick R., , \u2778 +1 more
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RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light [PDF]
, 2009 In nature, organisms are exposed to chronic low- dose ultraviolet light ( CLUV) as opposed to the acute high doses common to laboratory experiments. Analysis of the cellular response to acute high-dose exposure has delineated the importance of direct DNA
Carr, Antony M +3 more
core +1 more source
Cell cycle checkpoint revolution: targeted therapies in the fight against malignant tumors
Frontiers in PharmacologyMalignant tumors are among the most important causes of death worldwide. The pathogenesis of a malignant tumor is complex and has not been fully elucidated. Studies have shown that such pathogenesis is related to abnormal cell cycle progression.
Guangming Song +10 more
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Nature Communications, 2017 The histone methyltransferase EZH2 silences genes by generating H3K27me3 marks. Here the authors use a 3D GC organoid and show EZH2 mediates germinal centre (GC) formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoints.
Wendy Béguelin +10 more
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Bifurcation analysis of a model of the budding yeast cell cycle
, 2004 We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae.
Battogtokh, Dorjsuren, Tyson, John J.
core +1 more source
Non-Classical P38 Map Kinase Functions: Cell Cycle Checkpoints and Survival
International Journal of Biological Sciences, 2009 The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the process of differentiation and cell death has grown considerably in the recent ...
Tina M. Thornton, Mercedes Rincon
doaj