Results 201 to 210 of about 6,610,084 (246)

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

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An overview of the cell cycle arrest protein, p21WAF1

Oral Oncology, 2000
p21, also known as WAF1, Cip1, Sdi1, Mda 6 and Cap20 is a cell cycle protein that regulates and can arrest the cell cycle in G1 or S phase (either dependent or independent of p53). Its role may be pivotal in many cell processes including differentiation and apoptosis. This brief overview provides a summary of its presently known functions and indicates
G R Ogden, G R Ogden
exaly   +4 more sources

Cell cycle arrest by oxaliplatin on cancer cells

Fundamental & Clinical Pharmacology, 2007
AbstractOxaliplatin (L‐OHP) is the only platinum compound to show activity in colorectal cancer. We evaluated the cytotoxicity of L‐OHP on four human cancer cell lines and its influence on the cell cycle, when treated during long exposure (72 h) and different post‐incubation times (24 or 72 h).
Sara, William-Faltaos, Dany, Rouillard, Philippe, Lechat, Gérard, Bastian   +3 more
openaire   +2 more sources

Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation [PDF]

Journal of Cell Biology, 2016
The molecular mechanisms that drive mammalian cardiomyocytes out of the cell cycle soon after birth remain largely unknown. Here, we identify telomere dysfunction as a critical physiological signal for cardiomyocyte cell-cycle arrest.
Tania Aguado Sanchez
exaly   +2 more sources

Quantification of Cell Cycle-Arresting Proteins

2012
Cellular senescence, which can be defined as a stress response preventing the propagation of cells that have accumulated potentially oncogenic alterations, is invariably associated with a permanent cell cycle arrest. Such an irreversible blockage is mainly mediated by the persistent upregulation of one or more cyclin-dependent kinase inhibitors (CKIs),
Oliver, Kepp, Isabelle, Martins, Laurie, Menger, Mickaël, Michaud, Sandy, Adjemian, Abdul Qader, Sukkurwala, Lorenzo, Galluzzi, Guido, Kroemer   +7 more
openaire   +2 more sources

Cell cycle arrest in Batten disease lymphoblast cells

Gene, 2013
Batten disease is an inherited neurodegenerative disorder caused by a CLN3 gene mutation. Batten disease is characterized by blindness, seizures, cognitive decline, and early death. Although apoptotic cell death is one of the pathological hallmarks of Batten disease, little is known about the regulatory mechanism of apoptosis in this disease. Since the
Sunyang, Kang, June-Bum, Kim, Tae-Hwe, Heo, Sung-Jo, Kim   +3 more
openaire   +2 more sources

The Senescence Arrest Program and the Cell Cycle

2014
All living organisms are subject to progressive loss of function and damage to their tissues, a process known as aging. At the cellular level, the accumulation of damage to DNA, proteins, and organelles induces cellular senescence, a stress-response pathway that likely influences the aging process.
Alessandro, Bitto, Elizabeth P, Crowe, Chad, Lerner, Claudio, Torres, Christian, Sell   +4 more
openaire   +2 more sources

Mechanisms of interferon-induced cell cycle arrest

Frontiers in Bioscience, 2000
The interferons (IFNs) are a group of cytokines, which in addition to their antiviral activity are capable of modulating a variety of cellular responses. One such prominent effect of IFNs is their potent antimitogenic action, which can be observed both on malignant and non-malignant cells of many different origins.
O, Sangfelt, S, Erickson, D, Grander
openaire   +2 more sources

Meiotic cell cycle arrest in mammalian oocytes

Journal of Cellular Physiology, 2010
AbstractMeiotic cell cycle in mammalian oocytes is a dynamic process that involves several stop/go channels. The cell cycle arrest in oocyte occurs at various stages such as diplotene, metaphase‐I (M‐I), metaphase‐II (M‐II), and so called metaphase‐like arrest (M‐III).
Anima, Tripathi, K V Prem, Kumar, Shail K, Chaube   +2 more
openaire   +2 more sources