Results 211 to 220 of about 6,610,084 (246)
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Reversal of p53-induced cell-cycle arrest
Molecular Carcinogenesis, 1999Activation of the tumor suppressor protein p53 can lead to arrest in both G1 and G2 stages of the cell cycle and, in some cells, to apoptotic cell death. In this study, we showed that the p53 response to a chemotherapeutic drug, actinomycin D, was reversible in both normal and tumor cells, even when a substantial proportion of tumor cells were ...
S, Bates, E S, Hickman, K H, Vousden
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Arresting cell cycles and the effect on wound healing
Surgical Clinics of North America, 2003Wounds that contain a significant number of fibroblasts that are arrested because of senescence, damaged DNA, or enduring quiescence do not heal. As the arrested population of cells decreases and more cells that divide and contribute to wound repair populate the wound, the wound is more likely to achieve closure.
Jerry S, Vande Berg, Martin C, Robson
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The role of Krs1 in cell cycle arrest
Drug News & Perspectives, 2003The Krs1 (kinase responsive to stress 1) kinase has been proposed to mediate signals initiated by various forms of cellular or environmental stress for the process of growth arrest and apoptosis. The functional role of Krs1 in cell growth arrest may involve a constant, stress-independent proteolytic modification of the full-length kinase p63(Krs1), via
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TGF-β: receptors and cell cycle arrest
Molecular and Cellular Endocrinology, 1996Transforming growth factor-beta (TGF-beta) is the prototypic member of a superfamily of proteins important in normal growth and development. The recent molecular cloning and characterization of TGF-beta receptors represents a major advance in our understanding of the mechanism of action of this cytokine.
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Cell cycle checkpoints: Arresting progress in mitosis
BioEssays, 1997AbstractCell cycle arrest in M phase can be induced by the failure of a single chromosome to attach properly to the mitotic spindle. The same cell cycle checkpoint mediates M phase arrest when cells are treated with drugs that either disrupt or hyperstabilize spindle microtubules.
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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Frontiers in Cell and Developmental Biology, 2021Parmjit Jat
exaly