Results 231 to 240 of about 10,588,993 (295)

SD-2102, a Novel PDK1 Inhibitor, Suppresses Lung Cancer Growth by Targeting PDK1/Akt Signaling Pathway. [PDF]

Biomol Ther (Seoul)
Namgung H, Park SY, Darlami O, Hwang JH, Kang JH, Lee Y, Shin D, Oh SH.   +7 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Splicing as an integrative layer linking cell cycle regulation, epigenetic dynamics, and environmental responses in plants. [PDF]

Front Plant Sci
Olimpio GV, de Araújo-Lopes BG, Gigier MO, Hemerly AS.   +3 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Mechanisms and Therapeutic Potential of Resveratrol: Focus on its Effect on Leukemia. [PDF]

Onco Targets Ther
Tabei T, Sharifi S, Mezginejad F.
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

The role of cell cycle-associated protein 1 (CAPRIN1) in diseases. [PDF]

PeerJ
Li C, Tang P, Fu Y, Ji R.
europepmc   +1 more source

Potential for pathogenic protein acylation in succinate dehydrogenase-deficient pheochromocytoma and paraganglioma. [PDF]

Endocr Relat Cancer
Zhou SX, Maher LJ.
europepmc   +1 more source

Ovarian cancer proteomic landscape changes across different pathological stages and biomarker-sets identified with integrative multiomics analysis. [PDF]

Front Endocrinol (Lausanne)
Wang Y, Fang Z, Xu N, Chen L, Zhan X.
europepmc   +1 more source