Results 241 to 250 of about 4,494,876 (293)

Retinoblastoma protein and the cell cycle

Current Opinion in Genetics & Development, 1993
Deregulation of the cell cycle may contribute one of the primary mechanisms through which cancer arises. Eukaryotic cell division has been found to be a strictly controlled process, involving response to both positive and negative external signals and assessment of the cell's internal state.
R E, Hollingsworth, C E, Hensey, W H, Lee   +2 more
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Farnesylated proteins and cell cycle progression

Journal of Cellular Biochemistry, 2001
Post-translational modification of proteins by the addition of a farnesyl group is critical for the function of a number of proteins involved in signal transduction. Farnesylation facilitates their membrane association and also promotes protein-protein interaction.
F, Tamanoi, J, Kato-Stankiewicz, C, Jiang, I, Machado, N, Thapar   +4 more
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Nuclear Proteins And The Cell Cycle

1972
Publisher Summary This chapter discusses the biochemistry of the cell cycle in continuously dividing cells and the biochemical events that are described in G0 cells stimulated to proliferate. It also focuses on the proteins of the mammalian nucleus and the role that they may play in the control of cellular proliferation.
G, Stein, R, Baserga
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Protein tyrosine nitration in the cell cycle

Biochemical and Biophysical Research Communications, 2011
Nitration of tyrosine residues in proteins is associated with cell response to oxidative/nitrosative stress. Tyrosine nitration is relatively low abundant post-translational modification that may affect protein functions. Little is known about the extent of protein tyrosine nitration in cells during progression through the cell cycle.
Min, Jia, Claudia, Mateoiu, Serhiy, Souchelnytskyi   +2 more
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Quantification of Cell Cycle-Arresting Proteins

2012
Cellular senescence, which can be defined as a stress response preventing the propagation of cells that have accumulated potentially oncogenic alterations, is invariably associated with a permanent cell cycle arrest. Such an irreversible blockage is mainly mediated by the persistent upregulation of one or more cyclin-dependent kinase inhibitors (CKIs),
Oliver, Kepp, Isabelle, Martins, Laurie, Menger, Mickaël, Michaud, Sandy, Adjemian, Abdul Qader, Sukkurwala, Lorenzo, Galluzzi, Guido, Kroemer   +7 more
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The retinoblastoma protein and cell cycle regulation

Trends in Genetics, 1992
Although the precise function of the retinoblastoma gene product, p110RB1, remains unknown, recent data suggest that it plays a role in the control of cellular proliferation by regulating transcription of genes required for a cell to enter or stay in a quiescent or G0 state, or for progression through the G1 phase of the cell cycle.
P A, Hamel, B L, Gallie, R A, Phillips
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The retinoblastoma protein and the regulation of cell cycling

Trends in Biochemical Sciences, 1992
Increasing attention has been focused on how the retinoblastoma (RB) protein regulates cell growth. Recent evidence indicates that it is a substrate for phosphorylation by cyclin-dependent kinase-cyclin complexes and suggests that this phosphorylation modulates the ability of this protein to regulate transit through the cell cycle, perhaps in its G1 ...
D, Cobrinik, S F, Dowdy, P W, Hinds, S, Mittnacht, R A, Weinberg   +4 more
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Ras proteins in the control of the cell cycle and cell differentiation

Cellular and Molecular Life Sciences CMLS, 2000
The Ras family of small GTPases includes three closely related proteins: H-, K-, and N-Ras. Ras proteins are involved in the transduction of signals elicited by activated surface receptors, acting as key components by relaying signals downstream through diverse pathways.
P, Crespo, J, León
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Protein synthesis during the cell cycle oF L5178Y cells

Experimental Cell Research, 1973
Abstract There are two peaks of 3H-leucine incorporation in the cell cycle of L5178Y cells. The first, during S stage, corresponds to a peak of 3H-leucine incorporation into the nuclear fraction. The second, during S or early G2, corresponds to a peak of 3H-leucine incorporation into the mitochondrial fraction. The rate of protein synthesis is unique
Roti roti, J, Okada, S, Eberle, H
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The cell cycle and the retinoblastoma protein family

Cancer and Metastasis Reviews, 1994
Tumor formation results from alterations in the control of normal cell proliferation. To further our understanding of the molecular mechanisms underlying the deregulation of cell proliferation much attention, over the past decade, has been focused on the function of proto-oncogenes. Cellular oncogenes are thought to be growth promoting.
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