Results 251 to 260 of about 10,588,993 (295)

Quantification of Cell Cycle-Arresting Proteins

2012
Cellular senescence, which can be defined as a stress response preventing the propagation of cells that have accumulated potentially oncogenic alterations, is invariably associated with a permanent cell cycle arrest. Such an irreversible blockage is mainly mediated by the persistent upregulation of one or more cyclin-dependent kinase inhibitors (CKIs),
Oliver, Kepp, Isabelle, Martins, Laurie, Menger, Mickaël, Michaud, Sandy, Adjemian, Abdul Qader, Sukkurwala, Lorenzo, Galluzzi, Guido, Kroemer   +7 more
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The retinoblastoma protein and cell cycle regulation

Trends in Genetics, 1992
Although the precise function of the retinoblastoma gene product, p110RB1, remains unknown, recent data suggest that it plays a role in the control of cellular proliferation by regulating transcription of genes required for a cell to enter or stay in a quiescent or G0 state, or for progression through the G1 phase of the cell cycle.
P A, Hamel, B L, Gallie, R A, Phillips
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The retinoblastoma protein and the regulation of cell cycling

Trends in Biochemical Sciences, 1992
Increasing attention has been focused on how the retinoblastoma (RB) protein regulates cell growth. Recent evidence indicates that it is a substrate for phosphorylation by cyclin-dependent kinase-cyclin complexes and suggests that this phosphorylation modulates the ability of this protein to regulate transit through the cell cycle, perhaps in its G1 ...
D, Cobrinik, S F, Dowdy, P W, Hinds, S, Mittnacht, R A, Weinberg   +4 more
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Ras proteins in the control of the cell cycle and cell differentiation

Cellular and Molecular Life Sciences CMLS, 2000
The Ras family of small GTPases includes three closely related proteins: H-, K-, and N-Ras. Ras proteins are involved in the transduction of signals elicited by activated surface receptors, acting as key components by relaying signals downstream through diverse pathways.
P, Crespo, J, León
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Protein synthesis during the cell cycle oF L5178Y cells

Experimental Cell Research, 1973
Abstract There are two peaks of 3H-leucine incorporation in the cell cycle of L5178Y cells. The first, during S stage, corresponds to a peak of 3H-leucine incorporation into the nuclear fraction. The second, during S or early G2, corresponds to a peak of 3H-leucine incorporation into the mitochondrial fraction. The rate of protein synthesis is unique
Roti roti, J, Okada, S, Eberle, H
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Cell cycle proteins in Alzheimer's disease: Plenty of wheels but no cycle

Journal of Alzheimer's Disease, 2002
Increased expression and function of cell cycle proteins in Alzheimer’s disease (AD) brain signifies exit of neurons from the G0 phase of the cell cycle. However we propose that neurons do not actively progress through various stages of the cell cycle and likely do not exit G1.
Robert, Bowser, Mark A, Smith
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The cell cycle and the retinoblastoma protein family

Cancer and Metastasis Reviews, 1994
Tumor formation results from alterations in the control of normal cell proliferation. To further our understanding of the molecular mechanisms underlying the deregulation of cell proliferation much attention, over the past decade, has been focused on the function of proto-oncogenes. Cellular oncogenes are thought to be growth promoting.
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Protein kinases and cell cycle control

Seminars in Cell Biology, 1994
Protein kinases play a central role in the regulation of the eukaryotic cell cycle. Recent research has concentrated on a particular family of protein kinases, the cyclin-dependent kinases (CDKs), and their involvement in regulating particular cell cycle transitions, such as the initiation of DNA synthesis (S phase) or of cell division (mitosis).
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Nuclear Proteins in Programming Cell Cycles

1980
Publisher Summary During mitosis, the bulk of the nuclear proteins are released to the cytoplasm and the chromosomes are condensed. The condensed chromosomes are not active templates for RNA synthesis. Nuclear RNA synthesis resumes when the released nuclear proteins begin returning to the reconstituting daughter nuclei.
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The role of protein stability in the cell cycle and cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1998
In addition to the examples mentioned above, other important regulators of cell proliferation such as cyclin D, cyclin E, p21, p27 are all potentially controlled by ubiquitin-mediated proteolysis. In several of these, phosphorylation has been shown to play a role in targeting the proteins for degradation.
S J, Elledge, J W, Harper
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