Results 251 to 260 of about 4,494,876 (293)

Protein kinases and cell cycle control

Seminars in Cell Biology, 1994
Protein kinases play a central role in the regulation of the eukaryotic cell cycle. Recent research has concentrated on a particular family of protein kinases, the cyclin-dependent kinases (CDKs), and their involvement in regulating particular cell cycle transitions, such as the initiation of DNA synthesis (S phase) or of cell division (mitosis).
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Nuclear Proteins in Programming Cell Cycles

1980
Publisher Summary During mitosis, the bulk of the nuclear proteins are released to the cytoplasm and the chromosomes are condensed. The condensed chromosomes are not active templates for RNA synthesis. Nuclear RNA synthesis resumes when the released nuclear proteins begin returning to the reconstituting daughter nuclei.
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The role of protein stability in the cell cycle and cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1998
In addition to the examples mentioned above, other important regulators of cell proliferation such as cyclin D, cyclin E, p21, p27 are all potentially controlled by ubiquitin-mediated proteolysis. In several of these, phosphorylation has been shown to play a role in targeting the proteins for degradation.
S J, Elledge, J W, Harper
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The retinoblastoma protein and the cell cycle.

Seminars in cancer biology, 1992
Although mutations of the retinoblastoma gene (RB1) contribute to malignant progression in many types of tumor, the role of RB1 mutation in cancer initiation is highly restricted to the rare embryonic tumor, retinoblastoma. However, RB1 is expressed and its product, p110RB1, is regulated through the cell cycle in many tissues. This apparent paradox may
M, Sopta, B L, Gallie, R M, Gill, P A, Hamel, M, Muncaster, E, Zacksenhaus, R A, Phillips   +6 more
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Cell Cycle Regulation by Protein Degradation

2014
Cell division is controlled by a highly regulated program to accurately duplicate and segregate chromosomes. An important feature of the cell cycle regulatory program is that key cell cycle proteins are present and active during specific cell cycle stages but are later removed or inhibited to maintain appropriate timing. The ubiquitin-proteasome system
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Not Just a Cell Cycle Protein

Science Signaling, 2010
Cyclin D controls gene transcription during mouse retinal development.
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Regulation of transcription by proteins that control the cell cycle

Nature, 1997
In eukaryotes, progression of a cell through the cell cycle is partly controlled at the level of transcriptional regulation. Yeast and mammalian cells use similar mechanisms to achieve this regulation. Although gaps still remain, progress has been made recently in connecting the links between the cell's cycle and its transcriptional machinery.
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Cell Cycle Proteins in Brain in Mild Cognitive Impairment: Insights into Progression to Alzheimer Disease

Neurotoxicity research, 2012
Jeriel T. R. Keeney, Aaron M. Swomley, Jessica L. Harris, Ada Fiorini, bullet Mihail, I. Mitov, bullet Marzia, Perluigi bullet, R. Sultana, bullet D Allan Butterfield   +9 more
semanticscholar   +1 more source

Cell cycle control in cancer

Nature Reviews Molecular Cell Biology, 2021
Cosetta Bertoli, Helen Matthews, Robertus De Bruin   +2 more
exaly  

Cell Cycle Regulation by Protein Kinases and Phosphatases

2001
The two main phases of the eukaryotic cell cycle are S phase, when DNA is replicated, and M phase (mitosis), when the duplicated chromosomes are segregated to the two daughter cells. S and M phases are separated by two so-called “gap” phases, G1 (prior to S) and G2 (prior to M), respectively.
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