Results 331 to 340 of about 1,825,024 (378)

Nuclear Proteins And The Cell Cycle

1972
Publisher Summary This chapter discusses the biochemistry of the cell cycle in continuously dividing cells and the biochemical events that are described in G0 cells stimulated to proliferate. It also focuses on the proteins of the mammalian nucleus and the role that they may play in the control of cellular proliferation.
Gary S. Stein, Renato Baserga
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Farnesylated proteins and cell cycle progression

Journal of Cellular Biochemistry, 2001
Post-translational modification of proteins by the addition of a farnesyl group is critical for the function of a number of proteins involved in signal transduction. Farnesylation facilitates their membrane association and also promotes protein-protein interaction.
Iara M. P. Machado, Nitika Thapar, Juran Kato-Stankiewicz, Chen Jiang, Fuyuhiko Tamanoi   +4 more
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Quantification of Cell Cycle-Arresting Proteins

2012
Cellular senescence, which can be defined as a stress response preventing the propagation of cells that have accumulated potentially oncogenic alterations, is invariably associated with a permanent cell cycle arrest. Such an irreversible blockage is mainly mediated by the persistent upregulation of one or more cyclin-dependent kinase inhibitors (CKIs),
Mickaël Michaud, Mickaël Michaud, Guido Kroemer, Oliver Kepp, Oliver Kepp, Lorenzo Galluzzi, Lorenzo Galluzzi, Laurie Menger, Laurie Menger, Sandy Adjemian, Sandy Adjemian, Abdul Qader Sukkurwala, Abdul Qader Sukkurwala, Isabelle Martins, Isabelle Martins   +14 more
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The retinoblastoma protein and the regulation of cell cycling

Trends in Biochemical Sciences, 1992
Increasing attention has been focused on how the retinoblastoma (RB) protein regulates cell growth. Recent evidence indicates that it is a substrate for phosphorylation by cyclin-dependent kinase-cyclin complexes and suggests that this phosphorylation modulates the ability of this protein to regulate transit through the cell cycle, perhaps in its G1 ...
Sibylle Mittnacht, Steven F. Dowdy, David Cobrinik, Philip W. Hinds, Robert A. Weinberg   +4 more
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The retinoblastoma protein and cell cycle regulation

Trends in Genetics, 1992
Although the precise function of the retinoblastoma gene product, p110RB1, remains unknown, recent data suggest that it plays a role in the control of cellular proliferation by regulating transcription of genes required for a cell to enter or stay in a quiescent or G0 state, or for progression through the G1 phase of the cell cycle.
Paul A. Hamel, Brenda L. Gallie, Robert A. Phillips   +2 more
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Expression of cell-cycle-related proteins and excitoxicity [PDF]

Amino Acids, 2002
Previous work from our laboratory has suggested the functional contribution of p53 to the cascade of events triggered by excitatory amino acids and leading to cell death in primary neurons. Here we show that this paradigm can be extended to cortical neurons treated with NMDA. We found that exposure of the cells to either 300 microM or 2 mM NMDA induced
UBERTI, Daniela Letizia, MELI E., MEMO, Maurizio   +2 more
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Protein tyrosine nitration in the cell cycle

Biochemical and Biophysical Research Communications, 2011
Nitration of tyrosine residues in proteins is associated with cell response to oxidative/nitrosative stress. Tyrosine nitration is relatively low abundant post-translational modification that may affect protein functions. Little is known about the extent of protein tyrosine nitration in cells during progression through the cell cycle.
Claudia Mateoiu, Serhiy Souchelnytskyi, Min Jia   +2 more
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Protein synthesis during the cell cycle oF L5178Y cells

Experimental Cell Research, 1973
Abstract There are two peaks of 3H-leucine incorporation in the cell cycle of L5178Y cells. The first, during S stage, corresponds to a peak of 3H-leucine incorporation into the nuclear fraction. The second, during S or early G2, corresponds to a peak of 3H-leucine incorporation into the mitochondrial fraction. The rate of protein synthesis is unique
Roti roti, J, Okada, S, Eberle, H
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The cell cycle and the retinoblastoma protein family

Cancer and Metastasis Reviews, 1994
Tumor formation results from alterations in the control of normal cell proliferation. To further our understanding of the molecular mechanisms underlying the deregulation of cell proliferation much attention, over the past decade, has been focused on the function of proto-oncogenes. Cellular oncogenes are thought to be growth promoting.
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Protein kinases and cell cycle control

Seminars in Cell Biology, 1994
Protein kinases play a central role in the regulation of the eukaryotic cell cycle. Recent research has concentrated on a particular family of protein kinases, the cyclin-dependent kinases (CDKs), and their involvement in regulating particular cell cycle transitions, such as the initiation of DNA synthesis (S phase) or of cell division (mitosis).
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