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Ras proteins in the control of the cell cycle and cell differentiation
Cellular and Molecular Life Sciences CMLS, 2000The Ras family of small GTPases includes three closely related proteins: H-, K-, and N-Ras. Ras proteins are involved in the transduction of signals elicited by activated surface receptors, acting as key components by relaying signals downstream through diverse pathways.
Piero Crespo, Javier León
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Science Signaling, 2010
Cyclin D controls gene transcription during mouse retinal development.
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Cyclin D controls gene transcription during mouse retinal development.
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Cell cycle proteins in Alzheimer's disease: Plenty of wheels but no cycle
Journal of Alzheimer's Disease, 2002Increased expression and function of cell cycle proteins in Alzheimer’s disease (AD) brain signifies exit of neurons from the G0 phase of the cell cycle. However we propose that neurons do not actively progress through various stages of the cell cycle and likely do not exit G1.
Robert Bowser, Mark A. Smith
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Control of the yeast cell cycle by protein synthesis*1
Experimental Cell Research, 1982The increased synthesis of ribosomal RNA (rRNA) is correlated with enhanced cell proliferation, and it has been suggested that rRNA metabolism may have a regulatory role in the progression of the cell cycle. Alternatively, it might be the ensuing more active protein synthesis that drives the cell cycle progression. We have found that treatment with low
Popolo, L +2 more
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On the importance of protein phosphorylation in cell cycle control [PDF]
Molecular and Cellular Biochemistry, 1993 This chapter is written as a contribution to a volume commemorating the work of Krebs and Fischer that led to awarding of the Nobel Prize in 1992. This award was made because of their fundamental discovery in the mid-1950s that protein phosphorylation was the underlying mechanism that accounted for the reversible modification of activity of glycogen ...
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Cell Cycle-Related Protein Kinases and T Cell Death
1995Programmed cell death (PCD), or apoptosis, involves the activation of a specific suicide program within a cell. PCD is responsible for such diverse activities as the elimination of cells during normal embryological development and determination of the immune receptor repertoire (1–9).
Jialing Xiang +3 more
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[The roles of activated protein-1 and cell cycle protein in silica-induced cell cycle changes].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2011To investigate the roles of cyclin D1 and CDK4 in the cell cycle changes of human embryonic lung fibroblasts (HELFs) exposed to silica.HELFs were divided into 4 groups: control group, curcumin (20 µmol/L for 1 h) group, silica (200 µg/ml for 24 h) group and curcumin plus silica group, i.e.
Feng-mei Zhang +4 more
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Cell Cycle Regulation by Protein Degradation
2014Cell division is controlled by a highly regulated program to accurately duplicate and segregate chromosomes. An important feature of the cell cycle regulatory program is that key cell cycle proteins are present and active during specific cell cycle stages but are later removed or inhibited to maintain appropriate timing. The ubiquitin-proteasome system
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Protein suicide highlights the cell cycle [PDF]
Nature Methods, 2008 By exploiting the process of regulated protein death, researchers create a new class of fluorescent sensors that highlights cell-cycle transitions in living cells.
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Structural biology of cell-cycle proteins
Drug Discovery Today: TARGETS, 2004Abstract The master regulators of the eukaryotic cell cycle are cyclin-dependent protein kinases (CDKs), a highly conserved but functionally diverse enzyme family that also has essential roles in transcription, neuronal physiology, differentiation and apoptosis.
Sarah Major, Jane A Endicott
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