Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair
Nature Communications, 2017 The role of annexins in cell membrane repair is largely undefined. Here the authors use a model lipid bilayer to show that annexin A4 induces curvature at the membrane free edge and annexin A6 induces constriction force, and find that both annexins are ...
Theresa Louise Boye +7 more
doaj +1 more source
Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines [PDF]
, 2012 Background Fas expression and Fas-induced apoptosis are mechanisms attributed to the selective destruction of cells of the corpus luteum (CL) during luteal regression.
Birt, Alyssa +3 more
core +2 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Human peritoneal mesothelial cell death induced by high-glucose hypertonic solution involves Ca2+ and Na+ ions and oxidative stress with the participation of PKC/NOX2 and PI3K/Akt pathways [PDF]
, 2017 Indexación: Web of Science; Scopus.Chronic peritoneal dialysis (PD) therapy is equally efficient as hemodialysis while providing greater patient comfort and mobility. Therefore, PD is the treatment of choice for several types of renal patients. During PD,
Alejandro Pacheco +13 more
core +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Development of a Computational Model for Cell Activity in a Nano-Scaffold [PDF]
, 2020 Tissue engineering utilizes nano-scaffolds to direct cell growth and control cell behavior. Since cells occupy specific spaces within extracellular matrix (ECM) it’s important to understand how the geometry of these spaces influence cell behaviors such ...
Babcock, Ethan, Luke, Bethany
core +1 more source
Caspase-independent programmed cell death triggers Ca2PO4 deposition in an in vitro model of nephrocalcinosis [PDF]
, 2018 We provide evidence of caspase-independent cell death triggering the calcification process in GDNF-silenced HK-2 ...
Anglani F. +8 more
core +1 more source
A Multi-Stage Model of Cell Proliferation and Death: Tracking Cell Divisions with Erlang Distributions [PDF]
, 2021 Giulia Belluccini +3 more
openalex +1 more source