Results 101 to 110 of about 2,657,787 (357)

Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming

eLife, 2018
Understanding how cellular identity naturally interconverts with high efficiency and temporospatial precision is crucial for regenerative medicine. Here, we revealed a natural midgut-to-renal lineage conversion event during Drosophila metamorphosis and ...
Ke Xu, Xiaodan Liu, Yuchun Wang, Chouin Wong, Yan Song   +4 more
doaj   +1 more source

A Network of microRNAs Acts to Promote Cell Cycle Exit and Differentiation of Human Pancreatic Endocrine Cells. [PDF]

, 2019
Pancreatic endocrine cell differentiation is orchestrated by the action of transcription factors that operate in a gene regulatory network to activate endocrine lineage genes and repress lineage-inappropriate genes.
Carrano, Andrea C, Chiou, Joshua, Frazer, Kelly A, Gaertner, Bjoern, Jin, Wen, Kaestner, Klaus H, Matta, Ileana, Mulas, Francesca, Nguyen-Ngoc, Kim-Vy, Sander, Maike, Shih, Hung-Ping, Sui, Yinghui, Vinckier, Nicholas, Wang, Allen, Wang, Jinzhao, Zeng, Chun   +15 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

COMMITMENT DURING NEMATOCYTE DIFFERENTIATION IN HYDRA [PDF]

, 1981
Nematocytes in Hydra differentiate from interstitial stem cells. Desmonemes differentiate mainly in the distal half of the body column while stenoteles differentiate predominantly in the proximal half.
David, Charles N., Fujisawa, Toshitaka
core  

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes

eLife
Aging increases the risk of a myriad of chronic diseases, which are expensive and difficult to treat owing to their various risk factors. Repurposing existing medications has accelerated the development of therapies aimed at slowing aging. In this study,
Wencong Lyu, Haochen Wang, Zhehao Du, Ran Wei, Jianuo He, Fanju Meng, Jinlong Bi, Lijun Zhang, Chao Zhang, Yiting Guan, Wei Tao   +10 more
doaj   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Genome editing iPSC to purposing enhancement of induce CD8 killer T cell function for regenerative immunotherapy

Inflammation and Regeneration
In recent years, immunotherapy has become a standard cancer therapy, joining surgery, chemotherapy, and radiation therapy. This therapeutic approach involves the use of patient-derived antigen-specific T cells or genetically modified T cells engineered ...
Sota Kurihara, Akihiro Ishikawa, Shin Kaneko   +2 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Observational and experimental evidences relating to the origin and differentiation of the definitive germ cells in mice [PDF]

, 1943
Newton Everett
openalex   +1 more source