Results 121 to 130 of about 1,782,327 (317)

Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo [PDF]

, 2014
Here, we exploit the spatial separation of temporal events of neural differentiation in the elongating chick body axis to provide the first analysis of transcriptome change in progressively more differentiated neural cell populations in vivo.
Storey, Kate G, Barton, Geoffrey J, Song, Junfang, Storey, Kate G., Halley, Pamela A., Schurch, Nick, Barton, Geoffrey J., Das, Raman M., Li, Roman A, Olivera-Martinez, Isabel, Li, Roman A., Burt, Dave W, Burt, Dave W., Barton, Geoffrey J.; id_orcid, Halley, Pamela A, Li, Roman, Das, Raman M, Das, Raman M; id_orcid   +17 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Patterns of cell movement within the Dictyostelium slug revealed by cell type-specific, surface labeling of living cells [PDF]

, 1994
There are cells acattered in the rear, prespore region of the Dictyostelium slug that share many of the properties of the prestalk cells and that are therefore called anterior-like cells (ALCs).
Early, Anne, Abe, Tomoaki, Siegert, Florian, Weijer, Cornelis J., Williams, Jeffrey   +4 more
core   +1 more source

Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes

eLife
Aging increases the risk of a myriad of chronic diseases, which are expensive and difficult to treat owing to their various risk factors. Repurposing existing medications has accelerated the development of therapies aimed at slowing aging. In this study,
Wencong Lyu, Haochen Wang, Zhehao Du, Ran Wei, Jianuo He, Fanju Meng, Jinlong Bi, Lijun Zhang, Chao Zhang, Yiting Guan, Wei Tao   +10 more
doaj   +1 more source

Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs

Stem Cell Reports, 2015
Defects in articular cartilage ultimately result in loss of joint function. Repairing cartilage defects requires cell sources. We developed an approach to generate scaffoldless hyaline cartilage from human induced pluripotent stem cells (hiPSCs).
Akihiro Yamashita, Miho Morioka, Yasuhito Yahara, Minoru Okada, Tomohito Kobayashi, Shinichi Kuriyama, Shuichi Matsuda, Noriyuki Tsumaki   +7 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration [PDF]

, 2017
The loss of cone photoreceptors that mediate daylight vision represents a leading cause of blindness, for which cell replacement by transplantation offers a promising treatment strategy.
Naeem, A, Kloc, M., Decembrini, S, Sampson, R.D., Goh, D, Jonikas, M, Maswood, RN, Maswood, R.N., West, E.L., Sowden, J.C., Smith, A.J., Duran, Y, Sowden, JC, Gonzalez-Cordero, A, Arsenijevic, Y., Jonikas, M., Kruczek, K, Georgiadis, A., Pearson, R.A., Arsenijevic, Y, Gonzalez-Cordero, A., Sampson, RD, Ali, R.R., Kloc, M, Goh, D., Ali, RR, Blackford, SJI, Georgiadis, A, Pearson, RA, Duran, Y., Naeem, A., West, EL, Kruczek, K., Decembrini, S., Smith, AJ   +34 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Genes involved in spermatogonial stem cell self-renewal and differentiation [PDF]

, 2008
Spermatozoa are produced by the process of spermatogenesis. At the base of this process is a pool of spermatogonial stem cells that generate new stem cells as well as committed spermatogonia that will eventually differentiate in spermatozoa.
Genes/proteins responsible for the regulation of proliferation and differentiation of spermatogonial stem cells, van Bragt, M.P.A., Dep Biologie   +2 more
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source