Embryology of coccids, with especial reference to the formation of the ovary, origin and differentiation of the germ cells, germ layers, rudiments of the midgut, and the intracellular symbiotic organisms [PDF]
, 1919 Georgo Orihay Shinji
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Identification of Biomarkers Driving Blood Cell Development [PDF]
arXiv, 2019 A blood cell lineage consists of several consecutive developmental stages from the pluripotent or multipotent stem cell to a particular stage of terminally differentiated cells. There is considerable interest in identifying the key regulatory genes that govern blood cell development from the gene expression data without considering the underlying ...
arxiv
Molecular Oncology, EarlyView.The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang +3 more
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Advances in Lung Stem Cells and Lung Cancer Stem Cells
Chinese Journal of Lung Cancer, 2015 Cancer stem cells (CSCs) are emerging as a hot topic for cancer research. Lung CSCs share many characteristics with normal lung stem cells (SCs), including self-renewal and multi-potency for differentiation.
Huijing YIN, Jiong DENG
doaj +1 more source
Modelling of cell choice between differentiation and apoptosis on the basis of intracellular and extracellular regulations and stochasticity [PDF]
arXiv, 2016 The work is devoted to the analysis of cell population dynamics where cells make a choice between differentiation and apoptosis. This choice is based on the values of intracellular proteins whose concentrations are described by a system of ordinary differential equations with bistable dynamics.
arxiv
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
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Germ Cell Movements and Sex Differentiation of the Gonads in the Drosophila Embryo [PDF]
, 1941 B. P. Sonnenblick
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Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
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KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
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CD40 Ligand Rescues Inhibitor of Differentiation 3-Mediated G1Arrest Induced by Anti-IgM in WEHI-231 B Lymphoma Cells [PDF]
, 1923 Kikumi Hata +2 more
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