Results 131 to 140 of about 1,598,992 (308)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

DNA methylation variability in pediatric aplastic anaemia contributes to T-cell differentiation. [PDF]

Clin Transl Med
Lai J, Chen F, Miao Y, Zhang M, Zhu H, Liang H, Yang L, Zhang Y, Tang D, Luo C, Luo C, Li Y, Wang X, Liu Y, Chen J, Qin X, Wang X.   +16 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Addendum: TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

Nature Communications, 2018
Guoliang Lyu, Yiting Guan, Chao Zhang, Le Zong, Lei Sun, Xiaoke Huang, Li Huang, Lijun Zhang, Xiao-Li Tian, Zhongjun Zhou, Wei Tao   +10 more
doaj   +1 more source

SwitchTFI: identifying transcription factors driving cell differentiation. [PDF]

Genome Biol
Martini P, Hartebrodt A, de Almeida GP, Hackstein CP, Zehn D, Blumenthal DB.   +5 more
europepmc   +1 more source

TWIST1 Promotes the Odontoblast-like Differentiation of Dental Stem Cells

, 2011
Y. Li, Yao Lu, Izabela Maciejewska, Kerstin M. Galler, Adriana Cavender, Rena N. D’Souza   +5 more
openalex   +2 more sources

Denaturation and condensation of DNA in situ induced by acridine orange in relation to chromatin changes during growth and differentiation of friend erythroleukemia cells [PDF]

, 1985
Zbigniew Darżynkiewicz, Frank Traganos, Jan Kapuściński, Myron R. Melamed   +3 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The diagnostic implications of the pleural fluid cell differentiation. [PDF]

J Thorac Dis
Bansal K, Ee WW, Patole S, Medford A, Maskell N, Walker S, Arnold D.   +6 more
europepmc   +1 more source

P1649: GFI1B AND LSD1 REPRESS A MYELOID DIFFERENTIATION PROGRAM DURING INDUCED PLURIPOTENT STEM CELL DERIVED MEGAKARYOCYTE DIFFERENTIATION

, 2022
J. Venhuizen, M. van Bergen, D. Gilissen, Laura Wingens, Emile van den Akker, J. Jansen, Joost H.A. Martens, Bert van der Reijden   +7 more
openalex   +1 more source