Results 181 to 190 of about 1,598,992 (308)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A novel role for Hsc70-4 in blood cell differentiation in <i>Drosophila</i>. [PDF]

Front Immunol
Kharrat B, Gábor E, Vilmos P, Goins LM, Honti V.   +4 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Systemic chemotherapy in metastatic TNBC polarizes effector T cell differentiation. [PDF]

Cancer Cell Int
Ju HY, Yoon H, Jung S, Park SI, Kim TK, Han MR.   +5 more
europepmc   +1 more source

Preparation and evaluation of three-dimensional chitosan/graphene oxide/hydroxyapatite porous scaffolds on the proliferation and differentiation of bone mesenchymal stem cells

, 2016
Long Jia, Yanyan He, Yushi Yang, Mao Zhou, Tong Qiu, Qingzhi Wu   +5 more
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

The ionotropic AMPA receptor contributes to autoimmunity via altered regulatory T cell differentiation. [PDF]

iScience
Mitchell-Flack M, Higgins M, Zheng Y, Tam A, Goldschmidt H, Nishio H, Liu B, Cherry CM, Patatanian M, Blosser R, Mun SS, Suru A, Huganir R, Yu H, Pardoll D.   +14 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Stem cell-based approach to identify regulatory TFs during mammalian cell differentiation. [PDF]

Stem Cell Reports
Pei Y, Li S, Garipler G, Kamimoto K, Mazzoni EO.   +4 more
europepmc   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source