Results 181 to 190 of about 2,690,374 (356)

Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity

, 2021
Azusa Kobayashi, Ayaka Ito, Ibuki Shirakawa, Atsushi Tamura, Susumu Tomono, Hideo Shindou, Per Niklas Hedde, Miyako Tanaka, Naotake Tsuboi, Takuji Ishimoto, Sachiko Akashi‐Takamura, Shoichi Maruyama, Takayoshi Suganami   +12 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Addendum: TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging

Nature Communications, 2018
Guoliang Lyu, Yiting Guan, Chao Zhang, Le Zong, Lei Sun, Xiaoke Huang, Li Huang, Lijun Zhang, Xiao-Li Tian, Zhongjun Zhou, Wei Tao   +10 more
doaj   +1 more source

The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells

, 2015
Eszter Baricza, Viola Tamási, Nikolett Marton, Edit I. Buzás, György Nagy   +4 more
openalex   +2 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

SwitchTFI: identifying transcription factors driving cell differentiation. [PDF]

Genome Biol
Martini P, Hartebrodt A, de Almeida GP, Hackstein CP, Zehn D, Blumenthal DB.   +5 more
europepmc   +1 more source

Surface modifications by gas plasma control osteogenic differentiation of MC3T3-E1 cells

, 2012
Ana Barradas, Kristina Lachmann, Gregor Hlawacek, Cathelijne Frielink, Roman Truckenmoller, Otto C. Boerman, Raoul van Gastel, Henk Garritsen, Michael Thomas, Lorenzo Moroni, Clemens van Blitterswijk, Jan de Boer   +11 more
openalex   +2 more sources

Breed-dependent microRNA expression in the primary culture of skeletal muscle cells subjected to myogenic differentiation [PDF]

, 2018
Tomasz Sadkowski, Anna Ciecierska, J. Oprządek, Edyta Balcerek   +3 more
openalex   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source

The diagnostic implications of the pleural fluid cell differentiation. [PDF]

J Thorac Dis
Bansal K, Ee WW, Patole S, Medford A, Maskell N, Walker S, Arnold D.   +6 more
europepmc   +1 more source