Results 41 to 50 of about 11,748,111 (318)

Stem cell differentiation trajectories in Hydra resolved at single-cell resolution

Science, 2018
Mapping Hydra development cell by cell Hydra continually renews all cells in its body using three stem cell populations. This feature of Hydra allowed Siebert et al.
S. Siebert, J. A. Farrell, Jack F. Cazet, Yashodara Abeykoon, Abby S. Primack, C. Schnitzler, Celina E. Juliano   +6 more
semanticscholar   +1 more source

Heterogeneity and stochastic growth regulation of biliary epithelial cells dictate dynamic epithelial tissue remodeling

eLife, 2016
Dynamic remodeling of the intrahepatic biliary epithelial tissue plays key roles in liver regeneration, yet the cellular basis for this process remains unclear.
Kenji Kamimoto, Kota Kaneko, Cindy Yuet-Yin Kok, Hajime Okada, Atsushi Miyajima, Tohru Itoh   +5 more
doaj   +1 more source

Involvement of ST6Gal I‐mediated α2,6 sialylation in myoblast proliferation and differentiation

FEBS Open Bio, 2020
Myogenesis is a physiological process which involves the proliferation of myoblasts and their differentiation into multinucleated myotubes, which constitute the future muscle fibers.
Caroline Vergé, Amel Bouchatal, Frédéric Chirat, Yann Guérardel, Abderrahman Maftah, Jean‐Michel Petit   +5 more
doaj   +1 more source

Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived erythropoietin-producing cells

Scientific Reports, 2021
Erythropoietin (EPO) is a crucial hormone for erythropoiesis and produced by adult kidneys. Insufficient EPO production in chronic kidney disease (CKD) can cause renal anemia.
Naoko Katagiri, Hirofumi Hitomi, Shin-Ichi Mae, Maki Kotaka, Li Lei, Takuya Yamamoto, Akira Nishiyama, Kenji Osafune   +7 more
doaj   +1 more source

Cell Differentiation and Checkpoint [PDF]

International Journal of Cancer Research and Molecular Mechanisms ( ISSN 2381-3318 ), 2015
DNA damage is induced in many types of cells by internal and external cell stress. When DNA is damaged, DNA Damage Response (DDR) programs are activated to repair the DNA lesions in order to preserve genomic integrity and suppress subsequent malignant transformation.
Sara Cuesta Sancho, Toru Ouchi
openaire   +3 more sources

Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programs

Nature Communications, 2018
The genomic loci associated with B cell differentiation that are subject to transcriptional and epigenetic regulation in vivo are not well defined, leaving a gap in our understanding of the development of humoral immune responses.
Christopher D. Scharer, B. Barwick, M. Guo, Alexander P R Bally, J. Boss   +4 more
semanticscholar   +1 more source

Mouse WIF1 Is Only Modified with O-Fucose in Its EGF-like Domain III Despite Two Evolutionarily Conserved Consensus Sites

Biomolecules, 2020
The Wnt Inhibitory Factor 1 (Wif1), known to inhibit Wnt signaling pathways, is composed of a WIF domain and five EGF-like domains (EGF-LDs) involved in protein interactions.
Florian Pennarubia, Emilie Pinault, Bilal Al Jaam, Caroline E. Brun, Abderrahman Maftah, Agnès Germot, Sébastien Legardinier   +6 more
doaj   +1 more source

Transcription shapes DNA replication initiation to preserve genome integrity

Genome Biology, 2021
Background Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage.
Yang Liu, Chen Ai, Tingting Gan, Jinchun Wu, Yongpeng Jiang, Xuhao Liu, Rusen Lu, Ning Gao, Qing Li, Xiong Ji, Jiazhi Hu   +10 more
doaj   +1 more source

Therapeutic targets for metabolic dysfunction-associated steatotic liver disease and their roles in hepatocellular carcinoma

Exploration of Digestive Diseases, 2023
Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most common chronic liver diseases. Over time, there has been a significant increase in the prevalence of MASLD.
Chenyu Wei, Jianing Wu, Chaoyang Zhang, Yinshen Zhao, Chunzheng Li, Xianguang Yang   +5 more
doaj   +1 more source

Using Deep Learning to Predict Neural Stem Cell Differentiation in Regenerative Medicine [PDF]

arXiv, 2023
Over one in three people are affected by neurodegenerative disorders. Neural stem cells, which are multipotent regenerative cells with the potential to differentiate into any of the neural cell types, have immense therapeutic potential for treating neurological disorders.
arxiv