Results 231 to 240 of about 375,820 (259)

Targeting SIK2 with GRN-300 Potentiates Paclitaxel Efficacy in Triple-Negative Breast Cancer. [PDF]

Cancers (Basel)
Pina MA, Ozyurt R, Mao W, Yang H, Santiago-O'Farrill JM, Lu Z, Bast RC.   +6 more
europepmc   +1 more source

Case Report: Gangrene after one dose of investigational stannic pentetate radiopharmaceutical. [PDF]

Front Oncol
Myint ZW, El Khouli RH, Lemieux BP, Kunos CA.   +3 more
europepmc   +1 more source

Digitoxin inhibits the growth of HSC-3 cells by inducing G2/M cell cycle arrest and apoptosis. [PDF]

Transl Cancer Res
Rui Y, Wang Y, Gong H, Zhu X, Xu Q, Lin J, Wei J.   +6 more
europepmc   +1 more source

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Bombyx mori cell division cycle protein 37 promotes the proliferation of BmNPV

Pesticide Biochemistry and Physiology, 2021
Cell division cycle protein 37 (Cdc37) is a molecular chaperone that actively participates in many intracellular physiological and biochemical processes as well as pathogen infection. However, the function of Cdc37 in silkworm cells under Bombyx mori nucleopolyhedrovirus (BmNPV) infection is unknown.
Qian, Zhang, Yun-Fei, Wu, Peng, Chen, Tai-Hang, Liu, Zhan-Qi, Dong, Cheng, Lu, Min-Hui, Pan   +6 more
openaire   +2 more sources

Discovery and Optimization of Small Molecules Targeting the Protein–Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer

Journal of Medicinal Chemistry, 2020
Cell division cycle 37 (Cdc37) is known to work as a kinase-specific cochaperone, which selectively regulates the maturation of kinases through protein-protein interaction (PPI) with Hsp90. Directly disrupting the Hsp90-Cdc37 PPI is emerging as an alternative strategy to develop anticancer agents through a specific inhibition manner of kinase clients ...
Lei Wang, Jingsheng Jiang, Lixiao Zhang, Qiuyue Zhang, Jianrui Zhou, Li Li, Xiaoli Xu, Qidong You   +7 more
openaire   +2 more sources

Targeting Cell division cycle 37: A Promising Novel Therapeutic Strategy

ChemMedChem
Cell division cycle 37 (CDC37) is a kinase‐specific HSP90 cochaperone that stabilizes oncogenic kinases and is frequently overexpressed in malignancies, making it a compelling therapeutic target. Herein, we systematically delineate therapeutic strategies aimed at inhibiting CDC37, including modulating its Ser13 phosphorylation switch through CK2 ...
Lixiao Zhang, Yuting Xin, Qidong You, Lei Wang   +3 more
openaire   +2 more sources

Cell cycle control in cancer

Nature Reviews Molecular Cell Biology, 2021
Helen K Matthews, Cosetta Bertoli, Robertus A M De Bruin   +2 more
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