Results 11 to 20 of about 10,566 (169)
Deciphering tissue structure and function using spatial transcriptomics
Communications Biology, 2022 Walker et al. review methods used to analyse spatial transcriptomics data and discuss open questions and areas of future development.
Benjamin L. Walker +4 more
doaj +1 more source
Capturing Transitional Pluripotency through Proline Metabolism
Cells, 2022 In this paper, we summarize the current knowledge of the role of proline metabolism in the control of the identity of Embryonic Stem Cells (ESCs). An imbalance in proline metabolism shifts mouse ESCs toward a stable naïve-to-primed intermediate state of ...
Gabriella Minchiotti +4 more
doaj +1 more source
Histone Variants: Guardians of Genome Integrity
Cells, 2020 Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer.
Juliette Ferrand +2 more
doaj +1 more source
RSC and GRFs confer promoter directionality by restricting divergent noncoding transcription
Life Science Alliance, 2022 We show that the chromatin remodelling complex RSC and general regulatory factors (GRFs) limit transcription in the noncoding divergent direction, thereby increasing the directionality of promoters.
Andrew CK Wu +5 more
doaj +1 more source
Nerve regeneration by interferon intervention in aging brain
EMBO Molecular Medicine, 2023 Neural stem cells (NSCs) are shielded from viral infection by interferon (IFN) defense. As individuals age, activation of NSC decreases with a significant decline of stemness marker Sex‐determining region Y box 2 (Sox2) while IFN signaling enhances ...
Fanwen Wang, Duanqing Pei
doaj +1 more source
Multi-species single-cell transcriptomic analysis of ocular compartment regulons
Nature Communications, 2021 A comprehensive analysis of the ocular networks among various tissues is necessary to understand eye physiology in health and disease. Here the authors present a multi-species single-cell transcriptomic atlas consisting of cells of the cornea, iris ...
Pradeep Gautam +13 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Pig blastocyst-like structure models from embryonic stem cells
Cell DiscoveryPluripotent stem cells have the potential to generate embryo models that can recapitulate developmental processes in vitro. Large animals such as pigs may also benefit from stem-cell-based embryo models for improving breeding.
Jinzhu Xiang +9 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source