Results 31 to 40 of about 5,408,362 (316)
, 2023 The development of the mouse salivary gland involves a tip-driven process of branching morphogenesis that takes place in concert with differentiation into acinar, myoepithelial, and ductal (basal and luminal) sub -line-ages.
Bonkyoung Koo +7 more
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The UPR and cell fate at a glance [PDF]
Journal of Cell Science, 2010 In eukaryotic cells, secreted and resident proteins of the endomembrane system fold into their native structures within the endoplasmic reticulum (ER). The ER is a network of membranous tubules and sheets whose lumenal environment is crowded with molecular chaperones and protein-modification ...
Philip I, Merksamer, Feroz R, Papa
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Annual Review of Immunology, 2023 Many of the pathways that underlie the diversification of naive T cells into effector and memory subsets, and the maintenance of these populations, remain controversial. In recent years a variety of experimental tools have been developed that allow us to follow the fates of cells and their descendants.
De Boer, Rob J, Yates, Andrew J
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Comparative Analysis of Nuclear Transfer Embryo Derived Mouse Embryonic Stem Cells. Part II: Gene regulation [PDF]
, 2012 In a mouse model nuclear transfer embryo-derived embryonic stem cell lines (ntESCs) of various genetic backgrounds and donor cell types were compared with reference ESCs and analyzed comprehensively at molecular level as a second part of a larger study ...
Julianna Kobolak +17 more
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DNA Replication Stress and Cell Fate
, 2021 Faithful genome duplication through DNA replication is pivotal for genome maintenance. A variety of stresses could challenge this fundamental process and therefore endanger the genome integrity and change the cell fate.
Deng, L +4 more
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Nonsense-Mediated RNA Decay Influences Human Embryonic Stem Cell Fate [PDF]
, 2016 : Nonsense-mediated RNA decay (NMD) is a highly conserved pathway that selectively degrades specific subsets of RNA transcripts. Here, we provide evidence that NMD regulates early human developmental cell fate.
core +3 more sources
RSC and GRFs confer promoter directionality by restricting divergent noncoding transcription
Life Science Alliance, 2022 We show that the chromatin remodelling complex RSC and general regulatory factors (GRFs) limit transcription in the noncoding divergent direction, thereby increasing the directionality of promoters.
Andrew CK Wu +5 more
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Delta-like 4 is indispensable in thymic environment specific for T cell development. [PDF]
, 2008 The thymic microenvironment is required for T cell development in vivo. However, in vitro studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta-like (Dll)1 or Dll4, they differentiate into the T cell lineage in the ...
Holländer, Georg +30 more
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Following the fate of cells in vivo [PDF]
Lab Animal, 2020 Researchers are building better barcodes and combining spatial and temporal tools to trace cell lineages from the earliest stages of animal development—and beyond.
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Nerve regeneration by interferon intervention in aging brain
EMBO Molecular Medicine, 2023 Neural stem cells (NSCs) are shielded from viral infection by interferon (IFN) defense. As individuals age, activation of NSC decreases with a significant decline of stemness marker Sex‐determining region Y box 2 (Sox2) while IFN signaling enhances ...
Fanwen Wang, Duanqing Pei
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