Results 41 to 50 of about 1,346,147 (353)
Frontiers in Cell and Developmental Biology, 2021 The phenomenon of mitochondria donation is found in various tissues of humans and animals and is attracting increasing attention. To date, numerous studies have described the transfer of mitochondria from stem cells to injured cells, leading to increased
Marina O. Gomzikova +5 more
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Disruption of HOX activity leads to cell death that can be enhanced by the interference of iron uptake in malignant B cells. [PDF]
, 2010 The HOX genes encode a family of transcription factors that are dysregulated in several malignancies and have been implicated in oncogenesis and cancer cell survival.
Daniels, TR +5 more
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Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation [PDF]
, 1993 We have constructed a soluble chimeric fusion protein between the mouse CD8 alpha chain and the mouse CD40 T cell ligand. This protein binds to both human and mouse B cells.
Brocker, Thomas +5 more
core +1 more source
Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p [PDF]
, 2004 During mating, budding yeast cells reorient growth toward the highest concentration of pheromone. Bni1p, a formin homologue, is required for this polarized growth by facilitating cortical actin cable assembly.
Matheos, Dina +4 more
core +2 more sources
Viruses, 2022 Not all antibodies against SARS-CoV-2 inhibit viral entry, and hence, infection. Neutralizing antibodies are more likely to reflect real immunity; however, certain tests investigate protein/protein interaction rather than the fusion event.
Fabien Abdul +9 more
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Distinct Requirements for HIV-Cell Fusion and HIV-mediated Cell-Cell Fusion [PDF]
Journal of Biological Chemistry, 2015 Whether HIV-1 enters cells by fusing with the plasma membrane or with endosomes is a subject of active debate. The ability of HIV-1 to mediate fusion between adjacent cells, a process referred to as "fusion-from-without" (FFWO), shows that this virus can fuse with the plasma membrane.
Mariana Marin +4 more
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Cells, 2020 MacroH2A histone variants have functions in differentiation, somatic cell reprogramming and cancer. However, at present, it is not clear how macroH2As affect gene regulation to exert these functions.
Sarah Hurtado-Bagès +8 more
doaj +1 more source
Two cellular models for analyzing mitochondrial heteroplasmy [PDF]
Exploration of NeuroscienceAim: Mitochondria are essential for brain development, and the presence of different mitochondrial types is called mitochondrial heteroplasmy. Mitochondrial dysfunction is a central aspect of many people’s neurological diseases.
Yaning Hu +3 more
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Structural Basis of Eukaryotic Cell-Cell Fusion [PDF]
Cell, 2014 Cell-cell fusion proteins are essential in development. Here we show that the C. elegans cell-cell fusion protein EFF-1 is structurally homologous to viral class II fusion proteins. The 2.6 Å crystal structure of the EFF-1 trimer displays the same 3D fold and quaternary conformation of postfusion class II viral fusion proteins, although it lacks a ...
Marc Jamin +12 more
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A novel fusogenic herpes simplex virus for oncolytic virotherapy of squamous cell carcinoma
Virology Journal, 2011 Background R849 is a neurovirulent γ134.5 gene-deficient form of herpes simplex virus type 1 (HSV-1) and has LacZ genes at the deleted sites of the γ134.5 gene. HF is a spontaneously occurring, fusogenic HSV-1 strain.
Iwai Soichi +5 more
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