Results 41 to 50 of about 755,884 (339)

Structural Basis of Eukaryotic Cell-Cell Fusion [PDF]

Cell, 2014
Cell-cell fusion proteins are essential in development. Here we show that the C. elegans cell-cell fusion protein EFF-1 is structurally homologous to viral class II fusion proteins. The 2.6 Å crystal structure of the EFF-1 trimer displays the same 3D fold and quaternary conformation of postfusion class II viral fusion proteins, although it lacks a ...
Marc Jamin, Marc Jamin, Ahmed Haouz, Hadas Raveh-Barak, Félix A. Rey, Félix A. Rey, Clari Valansi, Benjamin Podbilewicz, Thomas Krey, Thomas Krey, Ori Avinoam, Jimena Pérez-Vargas, Jimena Pérez-Vargas   +12 more
openaire   +5 more sources

V-fusion: a convenient, nontoxic method for cell fusion

BioTechniques, 2010
Cell-to-cell fusion (cell fusion) is a fundamental biological process that also has been used as a versatile experimental tool to dissect a variety of cellular mechanisms, including the consequences of cell fusion itself, and to produce cells with ...
Amy Gottesman, Joseph Milazzo, Yuri Lazebnik   +2 more
doaj   +1 more source

Hematopoietic cancers and Nup98 fusions: determining common mechanisms of malignancy [PDF]

, 2012
Chromosomal aberrations are very frequent in leukemias and several recurring mutations capable of malignant transformation have been described. These mutations usually occur in hematopoietic stem cells (HSC), transforming them into leukemia stem cells.
arxiv   +1 more source

Resonant Ion Confinement Fusion Concept [PDF]

arXiv, 2022
Based on the theorized possibilities of resonant ion confinement, for a Deuteron cloud in a Penning-Malmberg trap with a specially configured rotating wall, the opportunity to design a new type of fusion device is prospected. It is proven that, for some trap configurations, nuclear fusion reactions should take place and, in that case, Lawson's ...
arxiv  

FOntCell: Fusion of Ontologies of Cells [PDF]

Frontiers in Cell and Developmental Biology, 2019
High-throughput cell-data technologies such as single-cell RNA-seq create a demand for algorithms for automatic cell classification and characterization. There exist several cell classification ontologies with complementary information. However, one needs to merge them to synergistically combine their information.
Javier Cabau-Laporta, Alex M. Ascensión, Mikel Arrospide-Elgarresta, Daniela Gerovska, Daniela Gerovska, Marcos J. Araúzo-Bravo, Marcos J. Araúzo-Bravo, Marcos J. Araúzo-Bravo, Marcos J. Araúzo-Bravo, Marcos J. Araúzo-Bravo, Marcos J. Araúzo-Bravo   +10 more
openaire   +6 more sources

Distinct Requirements for HIV-Cell Fusion and HIV-mediated Cell-Cell Fusion [PDF]

Journal of Biological Chemistry, 2015
Whether HIV-1 enters cells by fusing with the plasma membrane or with endosomes is a subject of active debate. The ability of HIV-1 to mediate fusion between adjacent cells, a process referred to as "fusion-from-without" (FFWO), shows that this virus can fuse with the plasma membrane.
Mariana Marin, Naoyuki Kondo, Tanay M. Desai, Jeong Hwa Kim, Gregory B. Melikyan   +4 more
openaire   +3 more sources

A viral fusogen hijacks the actin cytoskeleton to drive cell-cell fusion

eLife, 2020
Cell-cell fusion, which is essential for tissue development and used by some viruses to form pathological syncytia, is typically driven by fusogenic membrane proteins with tall (>10 nm) ectodomains that undergo conformational changes to bring apposing
Ka Man Carmen Chan, Sungmin Son, Eva M Schmid, Daniel A Fletcher   +3 more
doaj   +1 more source

ViralFP: A webserver of viral fusion proteins [PDF]

arXiv, 2021
Viral fusion proteins are attached to the membrane of enveloped viruses (a group that includes Coronaviruses, Dengue, HIV and Influenza) and catalyze fusion between the viral and host membranes, enabling the virus to insert its genetic material into the host cell.
arxiv  

Genetic basis of cell–cell fusion mechanisms [PDF]

Trends in Genetics, 2013
Cell-cell fusion in sexually reproducing organisms is a mechanism to merge gamete genomes and, in multicellular organisms, it is a strategy to sculpt organs, such as muscle, bone, and placenta. Moreover, this mechanism has been implicated in pathological conditions, such as infection and cancer.
Aguilar, P.S., Baylies, M.K., Fleissner, A., Helming, L., Inoue, N., Podbilewicz, B., Wang, H., and Wong, M.   +15 more
openaire   +5 more sources

Neurospora crassa NADPH Oxidase NOX-1 Is Localized in the Vacuolar System and the Plasma Membrane

Frontiers in Microbiology, 2019
The NADPH oxidases (NOX) catalyze the production of superoxide by transferring electrons from NADPH to O2, in a regulated manner. In Neurospora crassa NOX-1 is required for normal growth of hyphae, development of aerial mycelium and asexual spores, and ...
Nallely Cano-Domínguez, Barry Bowman, Leonardo Peraza-Reyes, Jesús Aguirre   +3 more
doaj   +1 more source