Results 71 to 80 of about 12,032,873 (351)
CCT4 promotes tunneling nanotube formation
FEBS Letters, EarlyView.Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto +3 more
wiley +1 more source
Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy
International Journal of Molecular Sciences, 2016 Cell fusion occurs in development and in physiology and rarely in those settings is it associated with malignancy. However, deliberate fusion of cells and possibly untoward fusion of cells not suitably poised can eventuate in aneuploidy, DNA damage and ...
J. Platt +3 more
semanticscholar +1 more source
Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes
FEBS Letters, EarlyView.The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji +3 more
wiley +1 more source
Cancer Medicine, 2019 Background We have previously reported the formation of polyploid giant cancer cells (PGCCs) through endoreduplication or cell fusion after cobalt chloride (CoCl2) induction. Cell fusion plays an important role in development and disease.
Fei Fei +8 more
doaj +1 more source
Frontiers in Microbiology, 2021 Halophilic archaea have been proposed to exchange DNA and proteins using a fusion-based mating mechanism. Scanning electron microscopy previously suggested that mating involves an intermediate state, where cells are connected by an intercellular bridge ...
Shamphavi Sivabalasarma +7 more
doaj +1 more source
International Journal of Molecular Sciences, 2016 Cell fusion is a physiological cellular process essential for fertilization, viral entry, muscle differentiation and placental development, among others. In this review, we will highlight the different cancer cell-cell fusions and the advantages obtained
Daniel Bastida-Ruiz +2 more
semanticscholar +1 more source
Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1
FEBS Letters, EarlyView.Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji +5 more
wiley +1 more source
Further Characterization of the Bifunctional HIV Entry Inhibitor sCD4-FIT45
Molecular Therapy: Nucleic Acids, 2017 HIV entry into target cells is a highly sequential and time-sensitive process. In recent years, potent HIV Env-targeting antibodies, such as VRC01, have been identified.
Alexander Falkenhagen, Sadhna Joshi
doaj +1 more source
Viruses, 2022 Herpes simplex virus 1 and 2 infections cause high unmet disease burdens worldwide. Mainly HSV-2 causes persistent sexually transmitted disease, fatal neonatal disease and increased transmission of HIV/AIDS.
Ursula A. Gompels +5 more
doaj +1 more source
British Journal of Surgery, 2005 Abstract This article continues the Journal's 2005 series of leaders highlighting areas where laboratory science meets clinical practice. In it Dr Holger Willenbring of the Oregon Stem Cell Center discusses the promise of therapeutic cell fusion and the difficulties that remain in bringing this technique into clinical practice.
openaire +2 more sources