Results 71 to 80 of about 755,884 (339)

Adaptive Patched Grid Mapping [PDF]

arXiv, 2023
In this work, we propose a novel adaptive grid mapping approach, the Adaptive Patched Grid Map, which enables a situational aware grid based perception for autonomous vehicles. Its structure allows a flexible representation of the surrounding unstructured environment.
arxiv  

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Formation of multinucleated osteoclasts depends on an oxidized species of cell surface-associated La protein

eLife
The bone-resorbing activity of osteoclasts plays a critical role in the life-long remodeling of our bones that is perturbed in many bone loss diseases. Multinucleated osteoclasts are formed by the fusion of precursor cells, and larger cells – generated ...
Evgenia Leikina, Jarred M Whitlock, Kamran Melikov, Wendy Zhang, Michael P Bachmann, Leonid Chernomordik   +5 more
doaj   +1 more source

“Keep on rolling”: circulating cells in a botryllid ascidian torpor

Frontiers in Ecology and Evolution, 2023
Hemocytes of the colonial tunicate Botrylloides leachii play important roles throughout the animal’s life span, including transport and storage of nutrients, respiration, regeneration, budding, sexual reproduction, defense responses, and tunic generation.
Yosef Hyams, Yosef Hyams, Julia Panov, Elizaveta Taranenko, Leonid Brodsky, Yuval Rinkevich, Baruch Rinkevich   +6 more
doaj   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Lipid exchange promotes fusion of model protocells [PDF]

arXiv, 2023
Vesicle fusion is an important process underlying cell division, transport, and membrane trafficking. In phospholipid systems, a range of fusogens including divalent cations and depletants have been shown to induce adhesion, hemifusion, and then full content fusion between vesicles.
arxiv  

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Monoclonal Antibody against Porcine LAG3 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection

Veterinary Sciences
Lymphocyte activation gene 3 (LAG3) is an inhibitory receptor and the interaction between fibrinogen-like protein 1 and LAG3 can inhibit the anti-tumor effect of T cells both in vivo and in vitro, which was regarded as a new immune evasion mechanism ...
Hui Wang, Xu Zheng, Danyang Zheng, Xiaoqian Wang, Zhiqian Zhao, Mi Zhao, Qiang Guo, Yang Mu   +7 more
doaj   +1 more source

A Microfluidic Flip-Chip Combining Hydrodynamic Trapping and Gravitational Sedimentation for Cell Pairing and Fusion

Cells, 2021
Cancer cell–immune cell hybrids and cancer immunotherapy have attracted much attention in recent years. The design of efficient cell pairing and fusion chips for hybridoma generation has been, subsequently, a subject of great interest.
Gaurav Pendharkar, Yen-Ta Lu, Chia-Ming Chang, Meng-Ping Lu, Chung-Huan Lu, Chih-Chen Chen, Cheng-Hsien Liu   +6 more
doaj   +1 more source

Mitochondrial network state scales mtDNA genetic dynamics [PDF]

, 2018
Mitochondrial DNA (mtDNA) mutations cause severe congenital diseases but may also be associated with healthy aging. MtDNA is stochastically replicated and degraded, and exists within organelles which undergo dynamic fusion and fission. The role of the resulting mitochondrial networks in the time evolution of the cellular proportion of mutated mtDNA ...
arxiv   +1 more source