The interplay between obesity and cancer: a fly view
Disease Models & Mechanisms, 2016 Accumulating epidemiological evidence indicates a strong clinical association between obesity and an increased risk of cancer. The global pandemic of obesity indicates a public health trend towards a substantial increase in cancer incidence and mortality.
Susumu Hirabayashi
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FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Growth of Streptococcus bovis and a Butyrivibrio in batch and continuous culture and the relationship of molar growth yield to intermicrobial competition : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Microbiology. [PDF]
, 1974 Cell growth yield of Streptococcus bovis and Butyrivibrio were determined in batch cultures where growth was separately limited by glucose, CO2 and trypticase.
Asmundson, Roderick Vincent
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An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
iPSC-derived neural organoids in dementia research: Recent advances and future directions
Neuroscience ResearchNeural organoids are self-assembled three-dimensionally shaped aggregates generated from pluripotent stem cells for the purpose of generating brain-like structures. The features of the disease, from molecular to functional levels, can be recapitulated by
Shogo Shima +2 more
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A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Modeling mutation-specific arrhythmogenic phenotypes in isogenic human iPSC-derived cardiac tissues
Scientific ReportsDisease modeling using human induced pluripotent stem cells (hiPSCs) from patients with genetic disease is a powerful approach for dissecting pathophysiology and drug discovery. Nevertheless, isogenic controls are required to precisely compare phenotypic
Thomas L. Maurissen +5 more
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Functional differential equations arising in cell-growth [PDF]
, 2009 Non-local differential equations are notoriously difficult to solve. Cell-growth models for population growth of a cohort structured by size, simultaneously growing and dividing, give rise to a class of non-local eigenvalue problems, whose “principal ...
Begg, R E, Wake, Graeme
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Synthetic Turing protocells: vesicle self-reproduction through symmetry-breaking instabilities
, 2006 The reproduction of a living cell requires a repeatable set of chemical events to be properly coordinated. Such events define a replication cycle, coupling the growth and shape change of the cell membrane with internal metabolic reactions.
Curry F.E +7 more
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The basic biology of erbB-2 and its participation in colorectal cancers [PDF]
, 2005 ErbB-2 is one of Tour cell surface growth factor receptors involved in transmission of signals controlling normal cell growth and differentiation. A range of growth factors serve as ligands, but none is specific for the ErbB-2 receptor.
Bryś, Magdalena +2 more
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