Results 91 to 100 of about 20,216,403 (408)
Nature Communications, 2021 The order of DNA methylation and histone modifications during transcription remained unclear. Here the authors show that HMGA2 induces DNA nicks at TGFB1-responsive genes, promoting nucleosome incorporation containing γ-H2AX, which is required for repair-
Stephanie Dobersch +21 more
doaj +1 more source
A quantitative study on the growth variability of tumour cell clones in vitro [PDF]
arXiv, 2007 Objectives: In this study, we quantify the growth variability of tumour cell clones from a human leukemia cell line. Materials and methods: We have used microplate spectrophotometry to measure the growth kinetics of hundreds of individual cell clones from the Molt3 cell line.
arxiv
KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway. [PDF]
, 2017 Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells ...
Chen, Miao +18 more
core +1 more source
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
A Simple Model of Cell Proliferation of Bacteria Using Min Oscillation [PDF]
, 2019 A mathematical model of Min oscillation in Escherichia coli is numerically studied. The oscillatory state and hysteretic transition are explained with simpler coupled differential equations. Next, we propose a simple model of cell growth and division using the Min oscillation. The cell cycle is not constant but exhibits fluctuation in the deterministic
arxiv +1 more source
Modeling Cell Size Distribution with Heterogeneous Flux Balance Analysis [PDF]
arXiv, 2023 For over two decades, Flux Balance Analysis (FBA) has been successfully used for predicting growth rates and intracellular reaction rates in microbiological metabolism. An aspect that is often omitted from this analysis, is segregation or heterogeneity between different cells.
arxiv
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
The effects of stochasticity at the single-cell level and cell size control on the population growth [PDF]
arXiv, 2016 Establishing a quantitative connection between the population growth rate and the generation times of single cells is a prerequisite for understanding evolutionary dynamics of microbes. However, existing theories fail to account for the experimentally observed correlations between mother-daughter generation times that are unavoidable when cell size is ...
arxiv
Interferons and cell growth control. [PDF]
Histology and histopathology, 2000 Cytokines modulate cell growth, differentiation, and immune defenses in the vertebrates. Interferons (IFNs) are a unique class of cytokines that stimulate antiviral, antitumor and antigen presentation by inducing the expression of several cellular genes. Recent studies have identified a novel gene regulatory pathway activated by IFNs, which serves as a
openaire +3 more sources
Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p [PDF]
, 2004 During mating, budding yeast cells reorient growth toward the highest concentration of pheromone. Bni1p, a formin homologue, is required for this polarized growth by facilitating cortical actin cable assembly.
Matheos, Dina +4 more
core +2 more sources