Results 101 to 110 of about 14,501,441 (297)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance

Frontiers in Oncology, 2019
Glioma Cancer Stem-Like Cells (GSCs) are a small subset of CD133+ cells with self-renewal properties and capable of initiating new tumors contributing to Glioma progression, maintenance, hierarchy, and complexity.
Antonio Lucena-Cacace, Masayuki Umeda, Lola E. Navas, Lola E. Navas, Amancio Carnero, Amancio Carnero   +5 more
doaj   +1 more source

Cell growth and cell cycle control

Molecular Biology of the Cell, 2013
mbc.E13-01-0002 Molecular Biology of the Cell Volume 24 Page 678 MBoC is pleased to publish this summary of the Minisymposium “Cell Growth and Cell Cycle Control” held at the American Society for Cell Biology 2012 Annual Meeting, San Francisco, CA, December 19, 2012.
openaire   +2 more sources

Identification of transcriptional and metabolic programs related to mammalian cell size [PDF]

, 2014
Background Regulation of cell size requires coordination of growth and proliferation. Conditional loss of cyclin-dependent kinase 1 in mice permits hepatocyte growth without cell division, allowing us to study cell size in vivo using transcriptomics and ...
Mlettinen, Teemu P., Pessa, Heli K. J., Bjoerklund, Mikael, Diril, M. Kasim, Sauer, Uwe; id_orcid, Fuhrer, Tobias, Kaldis, Philipp, Sauer, Uwe, Bjorklund, Mikael, DİRİL, MUHAMMED KASIM, Caldez, Matias J., Miettinen, Teemu P., Miettinen TP, Sauer U, Björklund M, Fuhrer T, Pessa HK, Diril MK, Caldez MJ, Kaldis P, Pessa, Heli K.J.   +20 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Quantitative analysis of cell types during growth and morphogenesis in Hydra [PDF]

, 1973
Tissue maceration was used to determine the absolute number and the distribution of cell types in Hydra. It was shown that the total number of cells per animal as well as the distribution of cells vary depending on temperature, feeding conditions, and ...
Bode, H., Schaller, H., David, C., Trenkner, E., Gierer, A., David, Charles N., Berking, S., E. Trenkner, H. Bode, H. Schaller, S. Berking, A. Gierer, C. N. David   +12 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Protein kinase C beta1 is implicated in the regulation of neuroblastoma cell growth and proliferation

, 2000
To investigate a putative involvement of protein kinase C (PKC) isoforms in supporting neuroblastoma cell proliferation, SK-N-BE(2) neuroblastoma cells were transfected with expression vectors coding for the C2 and V5 regions from different PKC isoforms.
Zeidman, Ruth,, Schultz, Anna,, Larsson, Christer,, Trollér, Ulrika,, Svensson, Karin, Lund University.   +5 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source