Results 91 to 100 of about 14,501,441 (297)

Human iPS cell-engineered three-dimensional cardiac tissues perfused by capillary networks between host and graft

Inflammation and Regeneration, 2018
Stem cell-based cardiac regenerative therapy is expected to be a promising strategy for the treatment of severe heart diseases. Pluripotent stem cells enabled us to reconstruct regenerated myocardium in injured hearts as an engineered tissue aiming for ...
Hidetoshi Masumoto, Jun K. Yamashita
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Modeling mutation-specific arrhythmogenic phenotypes in isogenic human iPSC-derived cardiac tissues

Scientific Reports
Disease modeling using human induced pluripotent stem cells (hiPSCs) from patients with genetic disease is a powerful approach for dissecting pathophysiology and drug discovery. Nevertheless, isogenic controls are required to precisely compare phenotypic
Thomas L. Maurissen, Masahide Kawatou, Víctor López-Dávila, Kenji Minatoya, Jun K. Yamashita, Knut Woltjen   +5 more
doaj   +1 more source

iPSC-derived neural organoids in dementia research: Recent advances and future directions

Neuroscience Research
Neural organoids are self-assembled three-dimensionally shaped aggregates generated from pluripotent stem cells for the purpose of generating brain-like structures. The features of the disease, from molecular to functional levels, can be recapitulated by
Shogo Shima, Takayuki Kondo, Haruhisa Inoue   +2 more
doaj   +1 more source

The interplay between obesity and cancer: a fly view

Disease Models & Mechanisms, 2016
Accumulating epidemiological evidence indicates a strong clinical association between obesity and an increased risk of cancer. The global pandemic of obesity indicates a public health trend towards a substantial increase in cancer incidence and mortality.
Susumu Hirabayashi
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Non-human primate preclinical model revealed the feasibility and short-term safety of iPSC-derived innate-like T cells in autologous transplantation

Frontiers in Immunology
BackgroundT cells derived from gene-edited induced pluripotent stem cells (iPSCs) are a promising alternative cell source for universal T-cell immunotherapy.
Yasuyuki Miyake, Shoichi Iriguchi, Ai Kawana-Tachikawa, Shuichi Kitayama, Eri Imai, Kahoru Taya, Hiroshi Ishii, Tomoyuki Miura, Hiromi Sakawaki, Tetsuro Matano, Tetsuro Matano, Shin Kaneko   +11 more
doaj   +1 more source

The coordination of cell growth during fission yeast mating requires Ras1-GTP hydrolysis [PDF]

, 2013
The spatial and temporal control of polarity is fundamental to the survival of all organisms. Cells define their polarity using highly conserved mechanisms that frequently rely upon the action of small GTPases, such as Ras and Cdc42.
Ladds, Graham, Wayne Croft, Bond, Michael, Croft Wayne, Cathryn Weston, Graham Ladds (430368), Graham Ladds, Cathryn Weston (471448), Croft, Wayne D., Michael Bond, Weston, Cathryn, Ladds Graham, Weston Cathryn, Bond Michael, Michael Bond (471449), Wayne Croft (471450)   +15 more
core   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source