Results 121 to 130 of about 14,501,441 (297)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

CSMA: A Standalone and ImageJ-Compatible Tool for Enhanced Wound Healing Assay Analysis

IEEE Access
Accurate quantification of wound closure in cell migration assays is crucial yet challenging. Still, existing methods often underperform due to omitting cell detection within the wound area, resulting in biased outcomes.
Tri Thanh Pham, Amina Sagymbayeva, Timur Elebessov, Zhadyra Onzhanova, Ferdinand Molnar   +4 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid

Nature Communications
Anti-pituitary-specific transcription factor (PIT)−1 hypophysitis is an autoimmune disease characterized by hormone secretion impairment from PIT-1-expressing pituitary cells, accompanied by malignancies with ectopic PIT-1 expression.
Keitaro Kanie, Takeshi Ito, Genzo Iguchi, Ryusaku Matsumoto, Keiko Muguruma, Shin Urai, Shuichi Kitayama, Hironori Bando, Masaaki Yamamoto, Hidenori Fukuoka, Wataru Ogawa, Shin Kaneko, Yutaka Takahashi   +12 more
doaj   +1 more source

Effect of Cell Growth and Proliferation Factors (EGF/PDGF Signaling Pathway) on the Etiopathogenesis of Intrauterine Growth Restriction [PDF]

Objective: It is likely that the subgroups of the epidermal growth factor/platelet-derived growth factor (EGF/PDGF) signaling pathway play a role in the etiopathogenesis of intrauterine growth restriction (IUGR).
Erhan Demirdağ, Emin Ümit Bağrıacık, Serhan Can İşcan, Merih Bayram, Melek Yaman, Bağrıaçık, Emin Ümit, Demirdağ, Erhan, İşcan, Serhan Can, Bayram, Merih, Yaman, MELEK   +9 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy

JACC: Basic to Translational Science
Summary: Cardiac fibrosis drives dysfunction in dilated cardiomyopathy (DCM); yet, effective therapies are limited. This study identifies FGFR1 as a critical target in cardiac fibrosis using transcriptomic and histological analyses of 58 human DCM ...
Reo Hata, MD, Shunsuke Funakoshi, MD, PhD, Takeru Makiyama, MD, PhD, Takao Kato, MD, PhD, Megumi Narita, BS, Yasuko Matsumura, MS, Ryoko Hirohata, MS, Yuki Naka, BS, Kazumi Ida, MS, Hiroaki Ito, MD, Akihiko Yoshizawa, MD, PhD, Yasuhito Nannya, MD, PhD, Hironori Haga, MD, PhD, Seishi Ogawa, MD, PhD, Koh Ono, MD, PhD, Takeshi Kimura, MD, PhD, Yoshinori Yoshida, MD, PhD   +16 more
doaj   +1 more source

Mechanisms of growth-dependent regulation of the Gin4 kinase

Cell cycle progression is dependent upon cell growth. Cells must therefore translate growth into a proportional signal that indicates when there has been sufficient growth for cell cycle progression.
Jasani, Akshi, Méndez Díaz, Francisco, Solano, Francisco, Kellogg, Douglas R., Prichard, Beth E., Sánchez -Godínez, David, Alcaide Gavilán, María   +6 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source