Results 51 to 60 of about 2,870,341 (212)

Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-Derived iPSCs

open access: yesStem Cell Reports, 2015
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by mutations of the survival of motor neuron 1 (SMN1) gene. In the pathogenesis of SMA, pathological changes of the neuromuscular junction (NMJ) precede the motor neuronal loss.
Michiko Yoshida   +13 more
doaj   +1 more source

Construction of a New Molecular Barcode for Discriminating Plants and Animals with a Close Genetic Relationship

open access: yesJournal of Integrative Agriculture, 2013
DNA barcodes have been proposed as a shortcut to provide species identification and as a way to accelerate the discovery of new species. A number of candidate gene regions have been suggested as possible barcodes for animals and plants, but for the ...
Li HUANG   +5 more
doaj   +1 more source

Cell facilitation promotes growth and survival under drug pressure in breast cancer [PDF]

open access: gold, 2023
Rena Emond   +9 more
openalex   +1 more source

Development of chimeric antigen receptor T cells targeting cancer-expressing podocalyxin

open access: yesRegenerative Therapy
Chimeric Antigen Receptor (CAR)-T cell therapy has revolutionized the treatment of CD19-positive B-cell malignancies. However, the field is rapidly evolving to target other antigens, such as podocalyxin (PODXL), a transmembrane protein implicated in ...
Yuta Mishima   +7 more
doaj   +1 more source

Truncation of Annexin A1 Is a Regulatory Lever for Linking Epidermal Growth Factor Signaling with Cytosolic Phospholipase A2 in Normal and Malignant Squamous Epithelial Cells [PDF]

open access: hybrid, 2007
Masakiyo Sakaguchi   +7 more
openalex   +1 more source

CSMA: A Standalone and ImageJ-Compatible Tool for Enhanced Wound Healing Assay Analysis

open access: yesIEEE Access
Accurate quantification of wound closure in cell migration assays is crucial yet challenging. Still, existing methods often underperform due to omitting cell detection within the wound area, resulting in biased outcomes.
Tri Thanh Pham   +4 more
doaj   +1 more source

Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid

open access: yesNature Communications
Anti-pituitary-specific transcription factor (PIT)−1 hypophysitis is an autoimmune disease characterized by hormone secretion impairment from PIT-1-expressing pituitary cells, accompanied by malignancies with ectopic PIT-1 expression.
Keitaro Kanie   +12 more
doaj   +1 more source

Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. [PDF]

open access: bronze, 1996
Ariane Mallat   +12 more
openalex   +1 more source

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