Results 51 to 60 of about 5,474,086 (199)

Multiscale modelling of cancer progression and treatment control : the role of intracellular heterogeneities in chemotherapy treatment [PDF]

open access: yes, 2015
Cancer is a complex, multiscale process involving interactions at intracellular, intercellular and tissue scales that are in turn susceptible to microenvironmental changes.
Chaplain, Mark Andrew Joseph   +1 more
core   +1 more source

Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissuesCentral MessagePerspective

open access: yesJTCVS Open, 2021
Objectives: To establish a protocol to prepare and transplant clinical-grade human induced pluripotent stem cell (hiPSC)-derived cardiac tissues (HiCTs) and to evaluate the therapeutic potential in an animal myocardial infarction (MI) model.
Hiroaki Osada, MD, PhD   +6 more
doaj   +1 more source

Artificial thymic organoid culture generates functional iPSC-derived CD4+ invariant natural killer T cells

open access: yesCommunications Biology
Invariant NKT (iNKT) cells have a T-cell receptor that is common to all individuals and are activated by recognizing glycolipids on MHC class I-like CD1d molecules.
Sara Shiina   +4 more
doaj   +1 more source

AMPK activation reverts mouse epiblast stem cells to naive state

open access: yesiScience, 2021
Summary: Despite increasing knowledge on primed and naive pluripotency, the cell signaling that regulates the pluripotency type in stem cells remains not fully understood.
Yajing Liu   +4 more
doaj   +1 more source

BMP2 is Superior to BMP4 for Promoting Human Muscle-Derived Stem Cell-Mediated Bone Regeneration in a Critical-Sized Calvarial Defect Model

open access: yesCell Transplantation, 2013
Muscle-derived cells have been successfully isolated using a variety of different methods and have been shown to possess multilineage differentiation capacities, including an ability to differentiate into articular cartilage and bone in vivo; however ...
Xueqin Gao   +9 more
doaj   +1 more source

Growth regulation in Hydra. Relationship between epithelial cell cycle length and growth rate [PDF]

open access: yes, 1984
The relationship between epithelial cell production and growth rate was investigated in Hydra attenuata under different feeding regimes. The increase of epithelial cell number was compared to the duration of the epithelial cell cycle using standard ...
Bosch, Thomas C. G., David, Charles N.
core   +1 more source

Compositions comprising citrate and applications thereof [PDF]

open access: yes, 2016
In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a ...
Yang, Jian
core   +1 more source

An In Vitro Human Liver Model by iPSC-Derived Parenchymal and Non-parenchymal Cells

open access: yesStem Cell Reports, 2017
Summary: During liver development, hepatoblasts and liver non-parenchymal cells (NPCs) such as liver sinusoidal endothelial cells (LSECs) and hepatic stellate cells (HSCs) constitute the liver bud where they proliferate and differentiate. Accordingly, we
Yuta Koui   +7 more
doaj   +1 more source

The Living Fossil Psilotum nudum Has Cortical Fibers With Mannan-Based Cell Wall Matrix

open access: yesFrontiers in Plant Science, 2020
Cell wall thickening and development of secondary cell walls was a major step in plant terrestrialization that provided the mechanical support, effective functioning of water-conducting elements and fortification of the surface tissues.
Tatyana Chernova   +6 more
doaj   +1 more source

Leptin Enhances Cholangiocarcinoma Cell Growth [PDF]

open access: yesCancer Research, 2008
Abstract Cholangiocarcinoma is a strongly aggressive malignancy with a very poor prognosis. Effective therapeutic strategies are lacking because molecular mechanisms regulating cholangiocarcinoma cell growth are unknown. Furthermore, experimental in vivo animal models useful to study the pathophysiologic mechanisms of malignant ...
G. Fava   +16 more
openaire   +2 more sources

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