Results 51 to 60 of about 5,434,917 (296)

Silicon consumption and population density changes of dominant planktonic diatoms in Lake Constance [PDF]

, 1983
(1) Interactions between silicon concentration and diatom growth have been studied in Lake Constance with data on number and volume of cells per unit volume of water and concentration of dissolved reactive silicon. (2) Concentration of dissolved reactive
Sommer, Ulrich, Stabel, H.-H.
core   +1 more source

Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissuesCentral MessagePerspective

JTCVS Open, 2021
Objectives: To establish a protocol to prepare and transplant clinical-grade human induced pluripotent stem cell (hiPSC)-derived cardiac tissues (HiCTs) and to evaluate the therapeutic potential in an animal myocardial infarction (MI) model.
Hiroaki Osada, MD, PhD, Masahide Kawatou, MD, PhD, Daiki Fujita, MS, Yasuhiko Tabata, PhD, DMedSci, DPharm, Kenji Minatoya, MD, PhD, Jun K. Yamashita, MD, PhD, Hidetoshi Masumoto, MD, PhD   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism [PDF]

, 2012
Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key ...
Clark, Peter M., Driggers, Edward M., Goddard, William A., III, Hill, Collin, Hsieh-Wilson, Linda C., Keenan, Marie C., Mason, Daniel E., Peters, Eric C., Yi, Wen   +8 more
core   +2 more sources

AMPK activation reverts mouse epiblast stem cells to naive state

iScience, 2021
Summary: Despite increasing knowledge on primed and naive pluripotency, the cell signaling that regulates the pluripotency type in stem cells remains not fully understood.
Yajing Liu, Junko Yamane, Akito Tanaka, Wataru Fujibuchi, Jun K. Yamashita   +4 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Deterministic and stochastic descriptions of gene expression dynamics

, 2012
A key goal of systems biology is the predictive mathematical description of gene regulatory circuits. Different approaches are used such as deterministic and stochastic models, models that describe cell growth and division explicitly or implicitly etc ...
A.M. Walczak, C. Tan, C.V. Rao, D.L. Cook, David Gomez, E. Andrianantoandro, E.M. Ozbudak, H. Bremer, H.H. McAdams, I. Golding, J. Hasty, J. Hasty, J. Paulsson, J. Paulsson, J. Peccoud, J. Yu, J.A. Bernstein, J.L. Spudich, K. Nath, L. Bintu, L. Cai, M. Kaern, M. Scott, M. Scott, M. Thattai, M.B. Elowitz, M.E. Csete, M.E. Wall, M.S. Ko, N. Brenner, N. Mitarai, N.A. Cookson, N.J. Guido, O.G. Berg, O.G. Berg, P. Guptasarma, P. Wang, P.S. Swain, R. Kwok, Rahul Marathe, S. Cooper, S. Cooper, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Reeh, Stefan Klumpp, U. Alon, Veronika Bierbaum, Y. Taniguchi   +51 more
core   +1 more source

Compositions comprising citrate and applications thereof [PDF]

, 2016
In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a ...
Yang, Jian
core   +1 more source

Genome editing iPSC to purposing enhancement of induce CD8 killer T cell function for regenerative immunotherapy

Inflammation and Regeneration
In recent years, immunotherapy has become a standard cancer therapy, joining surgery, chemotherapy, and radiation therapy. This therapeutic approach involves the use of patient-derived antigen-specific T cells or genetically modified T cells engineered ...
Sota Kurihara, Akihiro Ishikawa, Shin Kaneko   +2 more
doaj   +1 more source

Modified poloxamer 407 and hyaluronic acid thermosensitive hydrogel-encapsulated keratinocyte growth factor 2 improves knee osteoarthritis in rats

Materials & Design, 2021
Osteoarthritis (OA) is one of the most common chronic diseases, causing degenerative changes in articular cartilage and subchondral bones. To date, there is no effective drug to delay the progression of OA in clinical practice.
Rongshuai Yang, Min Chen, Xuanxin Yang, Wenzhe Sun, Chao Lu, Qi Hui, Changcan Shi, Xiaokun Li, Xiaojie Wang   +8 more
doaj   +1 more source