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Quo vadis cell growth and division? [PDF]
Frontiers in Cell and Developmental Biology, 2016 In animal cells and models, the control of cell growth and division is essential for the maintenance of cellular homeostasis and for cell proliferation. Defects in these pathways can lead to abnormal cell proliferation and eventually development of cancer.
Philipp Kaldis
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Mechanobiology of Cell Division in Plant Growth [PDF]
New Phytologist, 2021 SummaryCell division in plants is particularly important as cells cannot rearrange. It therefore determines the arrangement of cells (topology) and their size and shape (geometry). Cell division reduces mechanical stress locally by producing smaller cells and alters mechanical properties by reinforcing the mechanical wall network, both of which can ...
Sarah Robinson
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Regulatory Role of Cell Division Rules on Tissue Growth Heterogeneity
Frontiers in Plant Science, 2012 The coordination of cell division and cell expansion are critical to normal development of tissues. In plants, cell wall mechanics and the there from arising cell shapes and mechanical stresses can regulate cell division and cell expansion and thereby ...
Karen Alim +2 more
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Nature Communications, 2021 T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor ...
Shoichi Iriguchi +19 more
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Cytokinesis-based constraints on polarized cell growth in fission yeast. [PDF]
PLoS Genetics, 2012 The rod-shaped fission yeast Schizosaccharomyces pombe, which undergoes cycles of monopolar-to-bipolar tip growth, is an attractive organism for studying cell-cycle regulation of polarity establishment.
K Adam Bohnert, Kathleen L Gould
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How Cells Coordinate Growth and Division [PDF]
Current Biology, 2004 Size is a fundamental attribute impacting cellular design, fitness, and function. Size homeostasis requires a doubling of cell mass with each division. In yeast, division is delayed until a critical size has been achieved. In metazoans, cell cycles can be actively coupled to growth, but in certain cell types extracellular signals may independently ...
Jorgensen, Paul, Tyers, Mike
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F1000Research, 2013 Despite the universality of metabolic pathways, malignant cells were found to have their metabolism reprogrammed to generate energy by glycolysis even under normal oxygen concentrations (the Warburg effect).
Halina Witkiewicz +2 more
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F1000Research, 2013 Most cancer patients die of metastatic disease, not primary tumors, while biological mechanisms leading to metastases remain unclear and effective therapies are missing.
Halina Witkiewicz +2 more
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mSystems, 2023 Net growth of microbial populations, that is, changes in abundances over time, can be studied using 16S rRNA fluorescence in situ hybridization (FISH). However, this approach does not differentiate between mortality and cell division rates.
Jan D. Brüwer +8 more
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F1000Research, 2013 Inadequate understanding of cancer biology is a problem. This work focused on cellular mechanisms of tumor vascularization. According to earlier studies, the tumor vasculature derives from host endothelial cells (angiogenesis) or their precursors of bone
Halina Witkiewicz +2 more
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