Results 1 to 10 of about 619,300 (360)

Tip60-HDAC8-SMURF2-mediated β-TrCP1 degradation is a key mechanism for hypoxia-induced cell death and tissue injury [PDF]

Cellular and Molecular Life Sciences
The accumulation of HIFs regulated by the PHD-pVHL pathway represents the classical mechanism that transcriptionally mediates cellular adaptation to hypoxia. Extensive hypoxic stress activates cell death.
Sheng Li, Bo-Wen Zhang, Zi-Juan Wei, Yan Xi, Guo-An Zhang, Yue Zhang, De-Chi Kou, Xiao-Peng Song, Jing Huang, Ping Song, Ke-Yi Liang, Shuai-Shuai Pei, Hong-Yu Feng, Si-Ping Li, Qian-Qian Lou, Yue Liu, Kun-Hou Yao, Lu Yang, Su Chen   +18 more
doaj   +2 more sources

Hypoxia Onset in Mesenchymal Stem Cell Spheroids: Monitoring With Hypoxia Reporter Cells [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
The therapeutic and differentiation potential of human mesenchymal stems cells (hMSCs) makes these cells a promising candidate for cellular therapies and tissue engineering. On the path of a successful medical application of hMSC, the cultivation of cells in a three-dimensional (3D) environment was a landmark for the transition from simple two ...
Carola Schmitz, Ekaterina Potekhina, Teresa Irianto, Vsevolod V. Belousov, Vsevolod V. Belousov, Antonina Lavrentieva   +5 more
openaire   +4 more sources

Peroxiredoxin 1 alleviates oxygen-glucose deprivation/ reoxygenation injury in N2a cells via suppressing the JNK/caspase-3 pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Cerebral ischemia/reperfusion (I/R) injury inevitably aggravates the initial cerebral tissue damage following a stroke. Peroxiredoxin 1 (Prdx1) is a representative protein of the endogenous antioxidant enzyme family that regulates several ...
Yang Yuan, Hongchen Tan, Huailong Chen, Jiawen Zhang, Fei Shi, Mingshan Wang, Gaofeng Zhang, Haipeng Wang, Rui Dong   +8 more
doaj   +1 more source

Collagens Regulating Adipose Tissue Formation and Functions

Biomedicines, 2023
The globally increasing prevalence of obesity is associated with the development of metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver.
Iida Jääskeläinen, Tiina Petäistö, Elahe Mirzarazi Dahagi, Mahdokht Mahmoodi, Taina Pihlajaniemi, Mari T. Kaartinen, Ritva Heljasvaara   +6 more
doaj   +1 more source

Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function [PDF]

Arthritis Research & Therapy, 2009
With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies.
Walmsley, SR, Chilvers, ER, Whyte, MKB
openaire   +4 more sources

Hypoxia-Modified Cancer Cell Metabolism [PDF]

Frontiers in Cell and Developmental Biology, 2019
While oxygen is critical to the continued existence of complex organisms, extreme levels of oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive levels of oxygen), potentially promote stress within a defined biological environment.
Wafaa Al Tameemi, Tina P. Dale, Rakad M. Kh Al-Jumaily, Rakad M. Kh Al-Jumaily, Nicholas R. Forsyth   +4 more
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Tumor Hypoxia and Circulating Tumor Cells [PDF]

International Journal of Molecular Sciences, 2020
Circulating tumor cells (CTCs) are a rare tumor cell subpopulation induced and selected by the tumor microenvironment’s extreme conditions. Under hypoxia and starvation, these aggressive and invasive cells are able to invade the lymphatic and circulatory systems.
Tinganelli W., Durante M.
openaire   +5 more sources

Hypoxia Contributes to Poor Prognosis in Primary IDH-wt GBM by Inducing Tumor Cells MES-Like Transformation Trend and Inhibiting Immune Cells Activity

Frontiers in Oncology, 2021
AimsTo reveal the influence of hypoxia on tumor cells and immune cells in primary IDH-wt glioblastoma patients.MethodsSingle-cell RNA-seq data and bulk RNA-seq data were acquired from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA ...
Zujian Xiong, Zujian Xiong, Zujian Xiong, Hongwei Liu, Hongwei Liu, Chenqi He, Chenqi He, Xuejun Li, Xuejun Li   +8 more
doaj   +1 more source

Hypoxia and cancer cell metabolism [PDF]

Acta Biochimica et Biophysica Sinica, 2014
The past decade has witnessed a rapid accumulation of evidence showing that hypoxic microenvironment, which is typical during cancer development, plays key roles in regulating cancer cell metabolism. In this review, we will focus on the role of hypoxic response, particularly, its master regulator hypoxia-inducible factor-1, in regulating glucose, lipid,
De, Huang, Chenchen, Li, Huafeng, Zhang
openaire   +2 more sources

Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types. [PDF]

PLoS ONE, 2012
Hypoxia plays an important role in the resistance of tumour cells to chemotherapy. However, the exact mechanisms underlying this process are not well understood. Moreover, according to the cell lines, hypoxia differently influences cell death.
Audrey Sermeus, Marie Genin, Amélie Maincent, Maude Fransolet, Annick Notte, Lionel Leclere, Hélène Riquier, Thierry Arnould, Carine Michiels   +8 more
doaj   +1 more source