Results 1 to 10 of about 349,615 (316)

Peroxiredoxin 1 alleviates oxygen-glucose deprivation/ reoxygenation injury in N2a cells via suppressing the JNK/caspase-3 pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): Cerebral ischemia/reperfusion (I/R) injury inevitably aggravates the initial cerebral tissue damage following a stroke. Peroxiredoxin 1 (Prdx1) is a representative protein of the endogenous antioxidant enzyme family that regulates several ...
Yang Yuan, Hongchen Tan, Huailong Chen, Jiawen Zhang, Fei Shi, Mingshan Wang, Gaofeng Zhang, Haipeng Wang, Rui Dong   +8 more
doaj   +1 more source

Collagens Regulating Adipose Tissue Formation and Functions

Biomedicines, 2023
The globally increasing prevalence of obesity is associated with the development of metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver.
Iida Jääskeläinen, Tiina Petäistö, Elahe Mirzarazi Dahagi, Mahdokht Mahmoodi, Taina Pihlajaniemi, Mari T. Kaartinen, Ritva Heljasvaara   +6 more
doaj   +1 more source

Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types. [PDF]

PLoS ONE, 2012
Hypoxia plays an important role in the resistance of tumour cells to chemotherapy. However, the exact mechanisms underlying this process are not well understood. Moreover, according to the cell lines, hypoxia differently influences cell death.
Audrey Sermeus, Marie Genin, Amélie Maincent, Maude Fransolet, Annick Notte, Lionel Leclere, Hélène Riquier, Thierry Arnould, Carine Michiels   +8 more
doaj   +1 more source

Hypoxia Contributes to Poor Prognosis in Primary IDH-wt GBM by Inducing Tumor Cells MES-Like Transformation Trend and Inhibiting Immune Cells Activity

Frontiers in Oncology, 2021
AimsTo reveal the influence of hypoxia on tumor cells and immune cells in primary IDH-wt glioblastoma patients.MethodsSingle-cell RNA-seq data and bulk RNA-seq data were acquired from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA ...
Zujian Xiong, Zujian Xiong, Zujian Xiong, Hongwei Liu, Hongwei Liu, Chenqi He, Chenqi He, Xuejun Li, Xuejun Li   +8 more
doaj   +1 more source

Mast cell survival and mediator secretion in response to hypoxia. [PDF]

PLoS ONE, 2010
Tissue hypoxia is a consequence of decreased oxygen levels in different inflammatory conditions, many associated with mast cell activation. However, the effect of hypoxia on mast cell functions is not well established.
Magdalena Gulliksson, Ricardo F S Carvalho, Erik Ullerås, Gunnar Nilsson   +3 more
doaj   +1 more source

Multi-omics characterization of a scoring system to quantify hypoxia patterns in patients with head and neck squamous cell carcinoma

Journal of Translational Medicine, 2023
Background The 5-year survival rate of patients with head and neck squamous cell carcinoma (HNSCC) remains  
Cong Peng, Huiping Ye, Zhengyang li, Xiaofeng Duan, Wen Yang, Zhuguang Yi   +5 more
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Global gene expression profiling in three tumor cell lines subjected to experimental cycling and chronic hypoxia. [PDF]

PLoS ONE, 2014
Hypoxia is one of the most important features of the tumor microenvironment, exerting an adverse effect on tumor aggressiveness and patient prognosis.
Magdalena Olbryt, Anna Habryka, Sebastian Student, Michał Jarząb, Tomasz Tyszkiewicz, Katarzyna Marta Lisowska   +5 more
doaj   +1 more source

The role of tumour suppressor PDCD4 in beta cell death in hypoxia. [PDF]

PLoS ONE, 2017
Hypoxia is known to induce pancreatic beta cell dysfunction and apoptosis. Changes in Programmed Cell Death Gene 4 (PDCD4) expression have previously been linked with beta cell neogenesis and function. Our aim was to investigate the effects of hypoxia on
Sandeep Kumar, Claire E Marriott, Nouf F Alhasawi, Adrian J Bone, Wendy M Macfarlane   +4 more
doaj   +1 more source

Avaliação dos níveis séricos de testosterona em pacientes com síndrome da apneia obstrutiva do sono Evaluation of testosterone serum levels in patients with obstructive sleep apnea syndrome

Brazilian Journal of Otorhinolaryngology, 2011
Homens com síndrome da apneia obstrutiva do sono (SAOS) podem apresentar diminuição dos níveis de testosterona devido à hipóxia. OBJETIVOS: Relacionar os níveis séricos da testosterona, em pacientes com SAOS, com parâmetros clínico-laboratoriais ...
Fernando Drimel Molina, Marcela Suman, Thiago Bittencourt Ottoni de Carvalho, Vânia Belintani Piatto, Sebastião Roberto Taboga, José Victor Maniglia, Waldir Antônio Tognola   +6 more
doaj   +1 more source

The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro

Frontiers in Bioscience-Landmark, 2021
Objective: Nucleus pulposus cells (NPCs) are cells extracted from the intervertebral disc and are important for research into intervertebral disc degeneration (IVDD). NPCs live in an avascular and relatively hypoxic environment.
Xiao-Xin Gao, Chen-Hao Liu, Zhi-Lei Hu, Hai-Yin Li, Xian Chang, Yue-Yang Li, Yu-Yao Zhang, Yu Zhai, Chang-Qing Li   +8 more
doaj   +1 more source