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Hypoxia-Modified Cancer Cell Metabolism [PDF]
Frontiers in Cell and Developmental Biology, 2019 While oxygen is critical to the continued existence of complex organisms, extreme levels of oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive levels of oxygen), potentially promote stress within a defined biological
Tina P Dale, Nicholas R Forsyth
exaly +7 more sources
Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. [PDF]
PLoS One, 2017 Inflammation and hypoxia are hallmarks of inflammatory bowel disease. Low oxygen levels activate hypoxia-inducible factors as central transcriptional regulators of cellular responses to hypoxia, particularly in myeloid cells where hypoxia-inducible ...
Bäcker V +4 more
europepmc +2 more sources
Biological Research, 2019 Background/aims Hypoxia microenvironment plays a crucial role during tumor progression and it tends to exhibit poor prognosis and make resistant to various conventional therapies.
Nishant Kumar Rana +2 more
doaj +2 more sources
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy [PDF]
Hypoxia, 2015 Hypoxia is a non-physiological level of oxygen tension, a phenomenon common in a majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional vascularization and acquisition of epithelial-to-mesenchymal transition phenotype resulting ...
Azab, Abdel K +3 more
core +3 more sources
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Background Myocardial ischemia is the main reason for ischemic heart disease. Baicalin is a plant-derived flavonoid with cardio-protective activity.
Hailiang Yu, Bin Chen, Qi Ren
doaj +2 more sources
Peroxiredoxin 1 alleviates oxygen-glucose deprivation/ reoxygenation injury in N2a cells via suppressing the JNK/caspase-3 pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Cerebral ischemia/reperfusion (I/R) injury inevitably aggravates the initial cerebral tissue damage following a stroke. Peroxiredoxin 1 (Prdx1) is a representative protein of the endogenous antioxidant enzyme family that regulates several ...
Yang Yuan +8 more
doaj +1 more source
Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
Nature Reviews Molecular Cell Biology, 2020 Pearl Lee +2 more
exaly +2 more sources
Collagens Regulating Adipose Tissue Formation and Functions
Biomedicines, 2023 The globally increasing prevalence of obesity is associated with the development of metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver.
Iida Jääskeläinen +6 more
doaj +1 more source
Cancer Cell International, 2021 Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels supplying the tumor.
Asieh Emami Nejad +12 more
semanticscholar +1 more source
Nature Immunology, 2021 Cancer and chronic infections induce T cell exhaustion, a hypofunctional fate carrying distinct epigenetic, transcriptomic and metabolic characteristics. However, drivers of exhaustion remain poorly understood.
Nicole E. Scharping +11 more
semanticscholar +1 more source