Results 171 to 180 of about 599,693 (212)

Cell-Autonomous Metabolic Reprogramming in Hypoxia

Trends in Cell Biology, 2018
Molecular oxygen (O2) is a universal electron acceptor that enables ATP synthesis through mitochondrial respiration in all metazoans. Consequently, hypoxia (low O2) has arisen as an organizing principle for cellular evolution, metabolism, and (patho)biology, eliciting a remarkable panoply of metabolic adaptations that trigger transcriptional ...
Luana Schito, Sergio Rey
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Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance

2010
Hypoxia promotes tumor progression through multiple mechanisms including modifying angiogenesis, metabolism switch and invasion. Hypoxia inducible factors (HIFs), particularly HIF1α and HIF2α, are key mediators in cancer hypoxia response and high expression levels of HIFs correlate with a poor prognosis in various tumor types. Cancer stem cells (CSCs),
Zhizhong, Li, Jeremy N, Rich
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Hypoxia, reactive oxygen, and cell injury

Free Radical Biology and Medicine, 1989
Hypoxia usually decreases the formation of reactive oxygen species by oxidases and by autoxidation of components of cellular electron transfer pathways and of quinoid compounds such as menadione. In the case of menadione reactive oxygen species are liberated to a significant extent only at non-physiologically high oxygen partial pressures (PO2).
H, de Groot, A, Littauer
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Stem Cells, Hypoxia and Hypoxia-Inducible Factors

2009
Oxygen is a critical environmental factor that regulates the fate of stem cells. In this review, our aims are twofold: (i) to consider the contribution of oxygen tension to the environmental niches in which stem cells and their progeny find themselves and which have a role in determining their fate, and (ii) to define the regulatory networks that ...
Suzanne M. Watt, Grigorios Tsaknakis, Sinead P. Forde, Lee Carpenter   +3 more
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Cancer Stem Cells, Hypoxia and Metastasis

Seminars in Radiation Oncology, 2009
The successful growth of a metastasis, by definition, requires the presence of at least 1 cancer stem cell. Metastasis is a complex process, and an important contributor to this process is the influence of the tissue microenvironment, both cell-cell and cell-matrix interactions and the pathophysiologic conditions in tumors, such as hypoxia. A number of
Richard P, Hill, Delphine T, Marie-Egyptienne, David W, Hedley   +2 more
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Hypoxia-induced dedifferentiation in neuroblastoma cells

Cancer Letters, 2003
Hypoxia in solid tumors is associated with aggressive behavior and poor outcome. We recently discovered that hypoxia alters the expression of differentiation marker genes in neuroblastoma cells, in that the tumor cells adjust to the hypoxic environment by down-regulating genes associated with a neuronal and upregulating genes associated with a neural ...
Annika, Jögi, Ingrid, Øra, Helen, Nilsson, Lorenz, Poellinger, Håkan, Axelson, Sven, Påhlman   +5 more
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Hypoxia Tolerance of Coronary Endothelial Cells

1990
The coronary endothelium performs a great number of specific metabolic and physiological functions, e.g. the synthesis of autacoids, and the control of the transport of material into and out of the blood stream. For these performances a sufficient supply of metabolic energy is required. Alterations of the energetic state, e.g. due to an insufficient O2
T, Noll, P, Wissemann, S, Mertens, A, Krützfeldt, R, Spahr, H M, Piper   +5 more
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In vitro intermittent hypoxia: challenges for creating hypoxia in cell culture

Respiratory Physiology & Neurobiology, 2003
Intermittent hypoxia has been implicated in morbidities associated with sleep apnea, and may be a novel cellular signal for inflammation [J. Appl. Physiol. 90 (2001) 1986]. Standard cell culture has two major limitations for studying the effects of steady-state P(O(2)) and intermittent hypoxia.
James E, Baumgardner, Cynthia M, Otto
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Culture media from hypoxia conditioned endothelial cells protect human intestinal cells from hypoxia/reoxygenation injury

Experimental Cell Research, 2014
Remote ischemic preconditioning (RIPC) is a phenomenon, whereby short episodes of non-lethal ischemia to an organ or tissue exert protection against ischemia/reperfusion injury in a distant organ. However, there is still an apparent lack of knowledge concerning the RIPC-mediated mechanisms within the target organ and the released factors.
Lars, Hummitzsch, Karina, Zitta, Berthold, Bein, Markus, Steinfath, Martin, Albrecht   +4 more
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Barbiturates Protect Retinal Cells from Hypoxia in Cell Culture

Archives of Ophthalmology, 1989
A culture system was used to screen for drugs that can protect mammalian retinal cells from damage induced by hypoxia. Using a special incubator, cultures could be made hypoxic for defined periods. Phase contrast photomicroscopy facilitated comparison of retinal cells before hypoxia and 1 to 2 days after hypoxia.
J S, Pulido, M, Fukuda, C A, Howe, D G, Puro   +3 more
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